Role of Ovarian Hormones in Psychological Stress-induced Oxidative Organ Damage in Rats

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dc.authoridYegen, Berrak/0000-0003-0791-0165
dc.authoridYegen, Berrak C./0000-0003-0791-0165;
dc.authorwosidYegen, Berrak/O-6652-2017
dc.authorwosidYegen, Berrak C./ABA-1986-2020
dc.authorwosidYegen, Berrak/ABA-3274-2020
dc.contributor.authorMemi, Gulsun
dc.contributor.authorYegen, Berrak C.
dc.date.accessioned2024-06-12T11:03:37Z
dc.date.available2024-06-12T11:03:37Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Stress response varies with respect to gender via the hypothalamic-pituitary-gonadal axis. We aimed to investigate the effect of ovarian hormone deficiency on psychological stress response and oxidative damage. Methods: Female Sprague Dawley rats (250-300 g, n=56) were divided as control, sham, and ovariectomy (OVX) groups. Sham operation or surgical OVX were conducted under anesthesia. After 60 days, the rats were placed in a special chamber to induce psychological stress by electric shock and were kept in the same chamber for 30 min on the following 3 days. Glucocorticoid receptor antagonist RU-486 (10 mg/kg), oxytocin receptor antagonist atosiban (1 mg/kg), or saline was intraperitoneally administered 10 min before stress exposure. After the hole-board anxiety test, the rats were decapitated on the 4th day; tissue and blood samples were obtained. Results: Psychological stress increased cortisol levels in the RU-486-administered group, while cortisol levels were decreased in the atosiban-administered group. Serum interleukin (IL)-1 ss levels, but not TNF-alpha levels, were increased by inducing stress. Stress increased oxidative damage in the stomach, colon, and brain of ovariectomized rats (p<0.05-0.001), while atosiban partially reversed and RU-486 exaggerated oxidative damage. GSH levels that were depleted because of stress were partially replenished by administering atosiban; however, RU-486 had no effect on GSH levels. Conclusion: Although the absence of ovarian hormones during psychological stress had no effect on cortisol or anxiety levels, changes in cytokine levels and oxidative tissue damage were observed.en_US
dc.description.sponsorshipMarmara University Scientific Research Projects Commission [SAG-C-YLP-211009-0304]en_US
dc.description.sponsorshipThis study was supported by the Marmara University Scientific Research Projects Commission (SAG-C-YLP-211009-0304).en_US
dc.identifier.doi10.5152/clinexphealthsci.2016.04
dc.identifier.endpage79en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage72en_US
dc.identifier.urihttps://doi.org/10.5152/clinexphealthsci.2016.04
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21726
dc.identifier.volume6en_US
dc.identifier.wosWOS:000435279300004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherAves Press Ltden_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypothalamopituitary-Adrenal Axisen_US
dc.subjectHypothalamopituitary Gonadal Axisen_US
dc.subjectGlucocorticoid Receptoren_US
dc.subjectAtosibanen_US
dc.subjectOxytocinen_US
dc.titleRole of Ovarian Hormones in Psychological Stress-induced Oxidative Organ Damage in Ratsen_US
dc.typeArticleen_US

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