Evaluation of Glucose Metabolism and Cardiovascular Risk Factors in Prepubertal Girls with Premature Pubarche

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dc.authoridBezen, Diğdem/0000-0003-3977-5527
dc.authorwosidBezen, Diğdem/CAG-1901-2022
dc.contributor.authorBezen, Digdem
dc.contributor.authorKokenli, Filiz Tutunculer
dc.contributor.authorDilek, Emine
dc.contributor.authorSeleci, Didem Ag
dc.contributor.authorErbas, Hakan
dc.date.accessioned2024-06-12T11:12:49Z
dc.date.available2024-06-12T11:12:49Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Premature pubarche (PP) is a risk factor for metabolic syndrome (MS). The aim was to evaluate if glucose-insulin metabolism, cardiovascular risk factors, familial cardiovascular risk factors (FCVRF) created a risk for insulin resistance (IR) and if PP was a risk factor alone for MS in normal weight prepubertal girls with PP. Methods: Thirty-five prepubertal, non-obese girls with PP with normal birth weight and 35 age-matched control girls were evaluated for FCVRF, anthropometric measurements, blood pressure, lipid profile, fasting blood glucose-insulin, hemoglobin A1c (HbA1c), sex hormone binding globulin (SHBG), leptin, adiponectin, tumor necrosis factor-alpha (TNF-alpha), androgen levels, and bone age. Oral glucose tolerance test was performed in PP participants. Homeostasis model of assessment of IR (HOMA-IR), fasting glucose/insulin ratio, atherogenic index (AI), and free androgen index (FAI) were calculated. PP participants were further stratified by FCVRF. Results: HbA1c, lipid profile, testosterone, leptin, adiponectin, TNF-alpha, HOMA-IR, glucose/insulin ratio, AI, and fasting glucose-insulin levels were similar. In the PP group FAI was significantly higher (p=0.001), whereas SHBG was significantly lower (p=0.010) than the control group. Leptin levels of FCVRF+ and FCVRF-subgroups were 15.2 +/- 9.1 and 9.7 +/- 7.2 ng/mL, respectively and the difference was significant (p=0.016). Conclusion: As PP does not appear to be a risk factor alone for impaired glucose metabolism and IR in prepubertal non-obese girls with normal birth weight, it is our opinion that it is unnecessary to examine in detail such cases before puberty. Low SHBG levels in the PP group and high leptin levels in FCVRF+ subgroup might suggest that these may be predictive for MS in the future.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Institution [121]en_US
dc.description.sponsorshipThis study was supported by a project grant from the Trakya University Scientific Research Project Institution (TUEBAP date: 11.06.2013, approval no: 121).en_US
dc.identifier.doi10.4274/jcrpe.galenos.2022.2022-1-1
dc.identifier.endpage392en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue4en_US
dc.identifier.pmid35633646en_US
dc.identifier.scopus2-s2.0-85143180946en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage385en_US
dc.identifier.trdizinid1173353en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2022.2022-1-1
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1173353
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23314
dc.identifier.volume14en_US
dc.identifier.wosWOS:000908310600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofJournal Of Clinical Research In Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPremature Pubarcheen_US
dc.subjectPrepubertalen_US
dc.subjectLeptinen_US
dc.subjectGlucose Metabolismen_US
dc.subjectAdipocytokinesen_US
dc.subjectCardiovascular Risken_US
dc.subjectOvarian Hyperandrogenismen_US
dc.subjectInflammatory Markersen_US
dc.subjectPrecocious Pubarcheen_US
dc.subjectInsulin Sensitivityen_US
dc.subjectAdrenarcheen_US
dc.subjectHistoryen_US
dc.subjectObesityen_US
dc.subjectHyperinsulinemiaen_US
dc.subjectChildrenen_US
dc.subjectAssociationen_US
dc.titleEvaluation of Glucose Metabolism and Cardiovascular Risk Factors in Prepubertal Girls with Premature Pubarcheen_US
dc.typeArticleen_US

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