Etiological, clinical and biochemical characteristics of 367 children with early pubertal development from the Trakya region of Turkey

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dc.authoridKILAVUZ, SEBİLE/0000-0002-7527-2620
dc.authoridBezen, Diğdem/0000-0003-3977-5527
dc.authoridTutunculer, Filiz/0000-0003-3710-288X
dc.authorwosidKILAVUZ, SEBİLE/B-1682-2018
dc.authorwosidBezen, Diğdem/CAG-1901-2022
dc.contributor.authorKilavuz, Sebile
dc.contributor.authorBezen, Digdem
dc.contributor.authorSut, Necdet
dc.contributor.authorDilek, Emine
dc.contributor.authorTutunculer, Filiz
dc.date.accessioned2024-06-12T10:56:01Z
dc.date.available2024-06-12T10:56:01Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to describe etiologies, clinical findings, and compare anthropometric properties and biochemical characteristics of children with Precocious Puberty (PP).Materials and Methods: In this single-center study, 367 patients of whom medical records were reviewed diagnosed as premature thelarche (PT), premature adrenarche (PA), Central PP (CPP), and peripheral PP (PPP). The diagnosis was based on clinical, laboratory, and radiologic investigations and their follow-up.Results: During six years, 349 girls (%95,1) and 18 boys (%4,9) diagnosed as PP. The most common etiologies were CPP;127 (%34,6), PT;117 (%31,9), PA;112(%30,5) and PPP 11(%3), respectively. CPP group had significantly higher levels of height, weight, body mass index (BMI) and obesity/overweight incidence, estradiol (E2), basal luteinizing hormone (LH), peak LH, and peak LH/ follicle -stimulating hormone (FSH) ratio and higher uterine dimensions compared to the PT group while the PT group had significantly higher levels of peak FSH compared to the CPP group. It is impossible for the laboratory results to exactly match in each case with CPP, and the cases should be evaluated along with other clinical findings.Conclusion: Our study detected an increase in the frequency of girls referred to with PP signs. However, most children with PP were revealed as an incomplete type with a very low incidence of endocrine pathology. The complexity of pathogenesis in PP should lead us to be cautious about the consequences of PP in patients andevaluate their complaints, physical findings, and laboratory work-up seriously, such as a piece of a puzzle.en_US
dc.description.sponsorship8th Marmara Pediatric Congress (Istanbul) . [20-21.02.2022]en_US
dc.description.sponsorshipAcknowledgement: This study is presented as an oral presentation at the 8th Marmara Pediatric Congress (20-21.02.2022, Istanbul) .en_US
dc.identifier.doi10.17826/cumj.1176227
dc.identifier.endpage1423en_US
dc.identifier.issn2602-3032
dc.identifier.issn2602-3040
dc.identifier.issue4en_US
dc.identifier.startpage1412en_US
dc.identifier.trdizinid1149658en_US
dc.identifier.urihttps://doi.org/10.17826/cumj.1176227
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1149658
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19646
dc.identifier.volume47en_US
dc.identifier.wosWOS:000910852700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherCukurova Univ, Fac Medicineen_US
dc.relation.ispartofCukurova Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCentral Precocious Pubertyen_US
dc.subjectPremature Thelarcheen_US
dc.subjectPremature Adrenarcheen_US
dc.subjectEstradiolen_US
dc.subjectDHEA-Sen_US
dc.subjectFSHen_US
dc.subjectLHen_US
dc.subjectCentral Precocious Pubertyen_US
dc.subjectCongenital Adrenal-Hyperplasiaen_US
dc.subjectGirlsen_US
dc.subjectManagementen_US
dc.subjectOnseten_US
dc.subjectParametersen_US
dc.subjectDiagnosisen_US
dc.subjectLinken_US
dc.subjectAgeen_US
dc.titleEtiological, clinical and biochemical characteristics of 367 children with early pubertal development from the Trakya region of Turkeyen_US
dc.typeArticleen_US

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