Development of Atherosclerotic Cardiovascular Mortality in Gouty Arthritis and Rheumatoid Arthritis Patients: Are They Associated With Mean Platelet Volume and Neutrophil-Lymphocyte Ratio? A Comparative Study

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dc.contributor.authorMaden, Muhammet
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorPamuk, Omer Nuri
dc.date.accessioned2024-06-12T10:52:46Z
dc.date.available2024-06-12T10:52:46Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: This study aims to evaluate the mean platelet volume (MPV) and neutrophil-lymphocyte ratio (NLR) in gouty arthritis (GA) and rheumatoid arthritis (RA) patients, as well as their relationship with atherosclerotic cardiovascular mortality (ACVM). Patients and methods: The study included 122 GA patients (96 males, 26 females; mean age 64.6 +/- 13.4 years; range 34 to 82 years), 82 RA patients (40 males, 42 females; mean age 62.1 +/- 12.1 years; range 29 to 83 years), and 61 healthy controls (34 males, 27 females; mean age 65.3 +/- 4.8 years; range 33 to 80 years). Clinical and ACVM data were obtained from medical charts. Erythrocyte sedimentation rate, C-reactive protein, MPV, and NLR were recorded at the time of diagnosis and one month after therapy. Results: Mean platelet volume in GA (8.49 +/- 1.5) and RA (7.98 +/- 0.99) groups were significantly lower than in healthy controls (9.8 +/- 15) (p< 0.001). NLR in healthy controls (1.9 +/- 0.74) was significantly lower than in GA (3.6 +/- 2.3) and RA (3.7 +/- 2.5) groups (p< 0.001). After treatment, MPV did not change significantly in GA and RA groups (p values > 0.05); however, NLR decreased in both groups (p< 0.001). Nine GA and 12 RA patients died from ACVM during follow-up. GA patients with ACVM were older and had more frequent hypertension, higher MPV, and higher intercritical CRP level. In multivariate analysis, MPV was an independent poor prognostic factor for ACVM in GA patients. Conclusion: Gouty arthritis and RA patients had significantly lower MPV and significantly higher NLR than controls. MPV might be used as a potential biomarker for the development of ACVM in GA.en_US
dc.identifier.doi10.5606/ArchRheumatol.2017.6033
dc.identifier.endpage45en_US
dc.identifier.issn2148-5046
dc.identifier.issn1309-0283
dc.identifier.issue1en_US
dc.identifier.pmid30375526en_US
dc.identifier.scopus2-s2.0-85015290285en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage39en_US
dc.identifier.trdizinid238914en_US
dc.identifier.urihttps://doi.org/10.5606/ArchRheumatol.2017.6033
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/238914
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18828
dc.identifier.volume32en_US
dc.identifier.wosWOS:000396544400008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish League Against Rheumatismen_US
dc.relation.ispartofArchives Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectGouty Arthritisen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectNeutrophil/Lymphocyte Ratioen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectSystemic-Lupus-Erythematosusen_US
dc.subjectInflammatory Markeren_US
dc.subjectDiseaseen_US
dc.subjectRisken_US
dc.subjectClassificationen_US
dc.subjectCriteriaen_US
dc.titleDevelopment of Atherosclerotic Cardiovascular Mortality in Gouty Arthritis and Rheumatoid Arthritis Patients: Are They Associated With Mean Platelet Volume and Neutrophil-Lymphocyte Ratio? A Comparative Studyen_US
dc.typeArticleen_US

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