Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorKaplan, PB
dc.contributor.authorGücer, F
dc.contributor.authorSayin, NC
dc.contributor.authorYüksel, M
dc.contributor.authorYüce, MA
dc.contributor.authorYardim, T
dc.date.accessioned2024-06-12T11:03:34Z
dc.date.available2024-06-12T11:03:34Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women. Design: Case-control study. Setting: Clinical and academic research center. Patient(s): Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women. Main Outcome Measure(s): Serum levels of interleukin-1beta, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-alpha. Result(s): Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1beta and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-alpha levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9-140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1-35.8 pg/mL] and 12 pg/mL [4.3-68.2 pg/mL], respectively). Conclusion(s): Levels of TNF-alpha were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-alpha may be involved in the etiology of hyperemesis gravidarum.en_US
dc.identifier.doi10.1016/S0015-0282(02)04699-X
dc.identifier.endpage502en_US
dc.identifier.issn0015-0282
dc.identifier.issn1556-5653
dc.identifier.issue3en_US
dc.identifier.pmid12620429en_US
dc.identifier.scopus2-s2.0-0037338120en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage498en_US
dc.identifier.urihttps://doi.org/10.1016/S0015-0282(02)04699-X
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21690
dc.identifier.volume79en_US
dc.identifier.wosWOS:000181605000006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofFertility And Sterilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperemesis Gravidarumen_US
dc.subjectInterleukin-1 Betaen_US
dc.subjectInterleukin-2 Receptoren_US
dc.subjectInterieukin-6en_US
dc.subjectInterleukin-8en_US
dc.subjectTNF-Alphaen_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectHuman Chorionic-Gonadotropinen_US
dc.subjectFactor-Alphaen_US
dc.subject1st Trimesteren_US
dc.subjectInterleukin-6 Il-6en_US
dc.subjectEstradiol Levelsen_US
dc.subjectDouble-Blinden_US
dc.subjectTnf-Alphaen_US
dc.subjectNauseaen_US
dc.subjectSecretionen_US
dc.titleMaternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancyen_US
dc.typeArticleen_US

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