Maternal serum cytokine levels in women with hyperemesis gravidarum in the first trimester of pregnancy
Küçük Resim Yok
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: To compare serum cytokine levels in patients with hyperemesis gravidarum with levels in healthy pregnant and nonpregnant women. Design: Case-control study. Setting: Clinical and academic research center. Patient(s): Thirty women with hyperemesis gravidarum, 30 healthy women in the first trimester of pregnancy, and 30 healthy nonpregnant women. Main Outcome Measure(s): Serum levels of interleukin-1beta, interleukin-2 receptor, interleukin-6, interleukin-8, and tumor necrosis factor (TNF)-alpha. Result(s): Median serum levels of interleukin-2 receptor and interleukin-8 did not differ significantly among the three groups. Serum levels of interleukin-1beta and interleukin-6 were significantly higher in healthy pregnant women than in healthy nonpregnant women. Median TNF-alpha levels were significantly higher in women with hyperemesis (25.8 pg/mL [range, 4.9-140 pg/mL]) than in healthy pregnant and nonpregnant women (10.85 pg/mL [range, 4.1-35.8 pg/mL] and 12 pg/mL [4.3-68.2 pg/mL], respectively). Conclusion(s): Levels of TNF-alpha were significantly higher in patients with hyperemesis gravidarum than in healthy pregnant and nonpregnant women. Thus, TNF-alpha may be involved in the etiology of hyperemesis gravidarum.
Açıklama
Anahtar Kelimeler
Hyperemesis Gravidarum, Interleukin-1 Beta, Interleukin-2 Receptor, Interieukin-6, Interleukin-8, TNF-Alpha, Tumor-Necrosis-Factor, Human Chorionic-Gonadotropin, Factor-Alpha, 1st Trimester, Interleukin-6 Il-6, Estradiol Levels, Double-Blind, Tnf-Alpha, Nausea, Secretion
Kaynak
Fertility And Sterility
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
79
Sayı
3
