Serum total and lipid bound sialic acid levels in patients with benign and nonmelanom malignant skin tumors

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dc.contributor.authorKazezoglu, Cemal
dc.contributor.authorGoekmen, Selma Sueer
dc.contributor.authorSunar, Bendigar
dc.contributor.authorAygit, Cemal
dc.contributor.authorCakir, Beyhan
dc.date.accessioned2024-06-12T11:16:31Z
dc.date.available2024-06-12T11:16:31Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt has been reported that sialic acid containing oligosaccharides play an important role in the adhesion between cancer cells and endothelial cells and metastatic potential of tumor cells is proportional to cell surface sialylation. In the present study, we investigated whether there is a change in serum total and lipid bound sialic acid levels of patients with benign and non-melanom malignant skin tumors and, evaluated whether the measurement of sialic acid levels may be useful clinically in distinguishing patients with benign skin tumors from those with non-melanom malignant skin tumors. In this study, 27 patients with malignant skin tumors ( 16 men, age 50.78 +/- 12.46 years), 39 patients with benign skin tumors ( 17 men, age 48.59 +/- 16.23 years) were included. Serum total and lipid bound sialic acid determination was performed by the thiobarbituric acid method described by Warren and, the resorsinol method described by Katopodis, respectively. Student's T test and Z test were used to analyze the results. The mean serum total and lipid bound sialic acid levels were found to be 63.01 +/- 11.89 mg/dl and 15.77 +/- 2.44 mg/dl, respectively in patients with benign skin tumors; and 65.95 +/- 7.30 mg/dl and 16.70 +/- 3.80 mg/dl, respectively in patients with non-melanom malignant skin tumors. Serum total sialic acid and lipid bound sialic acid of patients with benign skin tumors were not different from those of patients with non-melanom malignant skin tumors. The percentage of lipid bound sialic acid was found to be 25.3 in patients with non-melanom malignant skin tumors, 25 in patients with benign skin tumors. There was no significant difference between the value of lipid bound sialic acid percentage in these groups. Our finding that there is no significant difference between serum total and lipid-bound sialic acid levels of patients with non melanom malignant skin tumors which are not able to metastase and patients with benign skin tumors supports the studies reporting that sialic acids play an important role in metastases.en_US
dc.identifier.endpage21en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue1en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24350
dc.identifier.volume32en_US
dc.identifier.wosWOS:000254852500003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTotal Sialic Aciden_US
dc.subjectLipid Bound Sialic Aciden_US
dc.subjectNon Melanom Malignant Skin Tumoren_US
dc.subjectBenign Skin Tumoren_US
dc.subjectCell-Surface Sialylationen_US
dc.subjectN-Acetylneuraminic Aciden_US
dc.subjectClinical-Significanceen_US
dc.subjectCanceren_US
dc.subjectMelanomaen_US
dc.subjectGlycoproteinen_US
dc.subjectMetastasisen_US
dc.subjectRecurrenceen_US
dc.subjectCarcinomaen_US
dc.subjectDiseasesen_US
dc.titleSerum total and lipid bound sialic acid levels in patients with benign and nonmelanom malignant skin tumorsen_US
dc.typeArticleen_US

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