Serum total and lipid bound sialic acid levels in patients with benign and nonmelanom malignant skin tumors
Küçük Resim Yok
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Walter De Gruyter Gmbh
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
It has been reported that sialic acid containing oligosaccharides play an important role in the adhesion between cancer cells and endothelial cells and metastatic potential of tumor cells is proportional to cell surface sialylation. In the present study, we investigated whether there is a change in serum total and lipid bound sialic acid levels of patients with benign and non-melanom malignant skin tumors and, evaluated whether the measurement of sialic acid levels may be useful clinically in distinguishing patients with benign skin tumors from those with non-melanom malignant skin tumors. In this study, 27 patients with malignant skin tumors ( 16 men, age 50.78 +/- 12.46 years), 39 patients with benign skin tumors ( 17 men, age 48.59 +/- 16.23 years) were included. Serum total and lipid bound sialic acid determination was performed by the thiobarbituric acid method described by Warren and, the resorsinol method described by Katopodis, respectively. Student's T test and Z test were used to analyze the results. The mean serum total and lipid bound sialic acid levels were found to be 63.01 +/- 11.89 mg/dl and 15.77 +/- 2.44 mg/dl, respectively in patients with benign skin tumors; and 65.95 +/- 7.30 mg/dl and 16.70 +/- 3.80 mg/dl, respectively in patients with non-melanom malignant skin tumors. Serum total sialic acid and lipid bound sialic acid of patients with benign skin tumors were not different from those of patients with non-melanom malignant skin tumors. The percentage of lipid bound sialic acid was found to be 25.3 in patients with non-melanom malignant skin tumors, 25 in patients with benign skin tumors. There was no significant difference between the value of lipid bound sialic acid percentage in these groups. Our finding that there is no significant difference between serum total and lipid-bound sialic acid levels of patients with non melanom malignant skin tumors which are not able to metastase and patients with benign skin tumors supports the studies reporting that sialic acids play an important role in metastases.
Açıklama
Anahtar Kelimeler
Total Sialic Acid, Lipid Bound Sialic Acid, Non Melanom Malignant Skin Tumor, Benign Skin Tumor, Cell-Surface Sialylation, N-Acetylneuraminic Acid, Clinical-Significance, Cancer, Melanoma, Glycoprotein, Metastasis, Recurrence, Carcinoma, Diseases
Kaynak
Turkish Journal Of Biochemistry-Turk Biyokimya Dergisi
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
32
Sayı
1
