The protective effect of amifostine on radiation-induced acute pulmonary toxicity

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorUzal, C
dc.contributor.authorDurmus-Altun, G
dc.contributor.authorCaloglu, M
dc.contributor.authorErgülen, A
dc.contributor.authorAltaner, S
dc.contributor.authorYigitbasi, NO
dc.date.accessioned2024-06-12T10:51:25Z
dc.date.available2024-06-12T10:51:25Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description16th Annual Congress of the European-Association-of-Nuclear-Medicine -- AUG 23-27, 2003 -- AMSTERDAM, NETHERLANDSen_US
dc.description.abstractPurpose: The purpose of this study was to determine by using Tc-99m-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model. Methods and Materials: Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD + AMF). The AMF and RAD + AMF groups received amifostine. The RAD and RAD + AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a Co-60 treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99)mTc-DTPA radioaerosol study was performed 14 day after irradiation. Results: The mean clearance rate of Tc-99m-DTPA in control subjects was 140 +/- 21 min. The highest It, value was noted in the RAD group (603 105 min, p = 0.001). There were no significant differences between the Tc-99m-DTPA lung clearance rates of the CONT, RAD + AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD + AMF are 63% 1.6%, 63% 2.5%, 60% 2.9%, and 63% 2%, respectively. Conclusions: We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury. (C) 2004 Elsevier Inc.en_US
dc.description.sponsorshipEuropean Assoc Nuclear Meden_US
dc.identifier.doi10.1016/j.ijrobp.2004.05.045
dc.identifier.endpage569en_US
dc.identifier.issn0360-3016
dc.identifier.issn1879-355X
dc.identifier.issue2en_US
dc.identifier.pmid15380593en_US
dc.identifier.scopus2-s2.0-4544234075en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage564en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijrobp.2004.05.045
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18360
dc.identifier.volume60en_US
dc.identifier.wosWOS:000223966500029en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal Of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAmifostineen_US
dc.subjectTc-99m-DTPA Lung Clearanceen_US
dc.subjectLungen_US
dc.subjectAcute Radiation Toxicityen_US
dc.subjectInduced Lung Injuryen_US
dc.subjectEpithelial Permeabilityen_US
dc.subjectMouse Lungen_US
dc.subjectAciden_US
dc.subjectRadioprotectionen_US
dc.subjectIrradiationen_US
dc.subjectExpressionen_US
dc.titleThe protective effect of amifostine on radiation-induced acute pulmonary toxicityen_US
dc.typeConference Objecten_US

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