The protective effect of amifostine on radiation-induced acute pulmonary toxicity
Küçük Resim Yok
Tarih
2004
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: The purpose of this study was to determine by using Tc-99m-diethylenetriaminepentaacetic acid (DTPA) lung scintigraphy whether amifostine given before irradiation protects alveolocapillary integrity in a rabbit model. Methods and Materials: Twenty white New Zealand rabbits were randomly divided into 4 groups: (1) control (CONT), (2) amifostine alone (AMF), (3) radiation (RAD), and (4) radiation plus amifostine (RAD + AMF). The AMF and RAD + AMF groups received amifostine. The RAD and RAD + AMF groups were irradiated to the right hemithorax with a single dose of 20 Gy using a Co-60 treatment unit. Amifostine (200 mg/kg) was given i.p. 30 min before irradiation. The (99)mTc-DTPA radioaerosol study was performed 14 day after irradiation. Results: The mean clearance rate of Tc-99m-DTPA in control subjects was 140 +/- 21 min. The highest It, value was noted in the RAD group (603 105 min, p = 0.001). There were no significant differences between the Tc-99m-DTPA lung clearance rates of the CONT, RAD + AMF (238 +/- 24 min), and AMF groups (227 +/- 54 min). The mean penetration index values of CONT, RAD, AMF, and RAD + AMF are 63% 1.6%, 63% 2.5%, 60% 2.9%, and 63% 2%, respectively. Conclusions: We concluded that amifostine treatment before the lung irradiation protects the lung alveolocapillary integrity. This study confirms the protective effect of amifostine in an acute phase of radiation lung injury. (C) 2004 Elsevier Inc.
Açıklama
16th Annual Congress of the European-Association-of-Nuclear-Medicine -- AUG 23-27, 2003 -- AMSTERDAM, NETHERLANDS
Anahtar Kelimeler
Amifostine, Tc-99m-DTPA Lung Clearance, Lung, Acute Radiation Toxicity, Induced Lung Injury, Epithelial Permeability, Mouse Lung, Acid, Radioprotection, Irradiation, Expression
Kaynak
International Journal Of Radiation Oncology Biology Physics
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
60
Sayı
2
