Biological variation estimates of prothrombin time, activated partial thromboplastin time, and fibrinogen in 28 healthy individuals

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dc.authoridhttp://orcid.org/0000-0001-7846-3476en_US
dc.contributor.authorFalay, Mesude
dc.contributor.authorSenes, Mehmet
dc.contributor.authorKorkmaz, Selcuk
dc.contributor.authorTurhan, Turan
dc.contributor.authorOkay, Murat
dc.contributor.authorOzturk, Berna Afacan
dc.contributor.authorYucel, Dogan
dc.contributor.authorOzet, Gulsum
dc.date.accessioned2019-06-26T06:46:52Z
dc.date.available2019-06-26T06:46:52Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik ve Tıbbi Bilişim Anabilim Dalıen_US
dc.descriptionKorkmaz, Selcuk (Trakya author)en_US
dc.description.abstractBackground Although tests of global hemostasis prothrombin time (PT) and activated partial thromboplastin time (aPTT) should not be used for prediction of bleeding risk, these tests are often used by many clinicians in daily practice particularly as a preoperative screening test. Robust biological variation (BV) data are needed for safe clinical applications of these tests. In this study, a stringent protocol was followed to estimate the BV's for PT, aPTT, and fibrinogen levels. Methods Results Weekly blood samples were obtained from 28 healthy individuals (18 females, 10 males) during 10 weeks study period. All measurements were performed with Stago STA-R coagulation analyzer. Prior to coefficient of variation (CV)-analysis of variance (ANOVA), the data were assessed for normality, trends, outliers, and variance homogeneity. Sex-stratified within-individual (CVI) and between-individual (CVG) BV estimates were determined for PT, aPTT, and fibrinogen tests. No difference was found between male and female estimates of BV. The observed CVI and CVG estimates were found to be lower than those previously published. Only for fibrinogen, CVI was higher than CVG. Conclusion Following a meticulous protocol, our study results provide up-to-date and more stringent BV estimates of global hemostasis tests.en_US
dc.identifier.citationFalay, M., Senes, M., Korkmaz, S., Turhan, T., Okay, M., Öztürk, B. A., ... & Ozet, G. (2018). Biological variation estimates of prothrombin time, activated partial thromboplastin time, and fibrinogen in 28 healthy individuals. International journal of laboratory hematology, 40(6), 721-725.en_US
dc.identifier.doi10.1111/ijlh.12910en_US
dc.identifier.endpage725en_US
dc.identifier.issue6en_US
dc.identifier.pmid30125477en_US
dc.identifier.scopus2-s2.0-85052657009en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage721en_US
dc.identifier.urihttps://doi.org/10.1111/ijlh.12910
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4229
dc.identifier.volume40en_US
dc.identifier.wosWOS:000450607300021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternational Journal of Laboratory Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectAPTTen_US
dc.subjectBiological Variationen_US
dc.subjectCoagulationen_US
dc.subjectFibrinogenen_US
dc.subjectHematologyen_US
dc.subjectPreanalytical Phaseen_US
dc.subjectPTen_US
dc.titleBiological variation estimates of prothrombin time, activated partial thromboplastin time, and fibrinogen in 28 healthy individualsen_US
dc.typeArticleen_US

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