The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorUgur-Altun, B
dc.contributor.authorAltun, A
dc.contributor.authorGerenli, M
dc.contributor.authorTugrul, A
dc.date.accessioned2024-06-12T11:09:29Z
dc.date.available2024-06-12T11:09:29Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description13th European Congress on Obesity -- MAY 26-29, 2004 -- Prague, CZECH REPUBLICen_US
dc.description.abstractAim: We investigated the relationship between insulin resistance and serum osteoprotegerin (OPG) levels in healthy obese subjects and healthy lean controls. Methods: Fifty obese subjects (age: 31 +/- 8 years) and 24 lean controls (age: 30 7 years) were included in the study. We used the homeostasis model assessment for insulin resistance (HOMA-IR) index as the index of insulin resistance. OPG levels were measured with the commercial ELISA kit. Obese subjects were studied in three groups: Group I (n = 25) HOMA-IR index < 2.24, Group II (n = 13) index 2.24-3.59, Group III (n = 12) index > 3.59. Group IV (n = 24) was the lean controls with HOMA-IR index < 2.24. Results: Obese subjects with increased insulin resistance (Group III) had lower OPG values than other groups (11.88 +/- 7.43 pg/ ml, 16.39 +/- 6.39 pg/ml, 17.37 +/- 9.61 pg/ml, and 18.1 +/- 6.65 pg/ml, respectively; Group I versus Group III p = 0.036; Group III versus Group IV p = 0.012). We also found significant inverse correlations between OPGc (corrected for BMI) and fasting glucose (r = -0.325, p = 0.005), fasting insulin (r = -0.404, p = 0.0001) as well as HOMA-IR (r = -0.428, p = 0.0001). Increased fibrinogen level was found in Group III than Group IV (9.32 +/- 1.97 mu mol/1 versus 7.47 +/- 1.65 mu mol/1, respectively; p = 0.005). In conclusion, insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels. The relationship between serum OPG levels and HOMA-IR may provide an insight into vascular endothelial dysfunction in obesity. (c) 2004 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.diabres.2004.10.011
dc.identifier.endpage222en_US
dc.identifier.issn0168-8227
dc.identifier.issn1872-8227
dc.identifier.issue3en_US
dc.identifier.pmid15936463en_US
dc.identifier.scopus2-s2.0-20144381987en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.1016/j.diabres.2004.10.011
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22831
dc.identifier.volume68en_US
dc.identifier.wosWOS:000230181900006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofDiabetes Research And Clinical Practiceen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectObesityen_US
dc.subjectInsulin Resistanceen_US
dc.subjectOsteoprotegerinen_US
dc.subjectAtherosclerosisen_US
dc.subjectEndothelial Dysfunctionen_US
dc.subjectNf-Kappa-Ben_US
dc.subjectHomeostasis Model Assessmenten_US
dc.subjectType-2 Diabetic-Patientsen_US
dc.subjectReceptor Activatoren_US
dc.subjectRank Liganden_US
dc.subjectAtherosclerosisen_US
dc.subjectCalcificationen_US
dc.titleThe relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesityen_US
dc.typeConference Objecten_US

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