The relationship between insulin resistance assessed by HOMA-IR and serum osteoprotegerin levels in obesity
Küçük Resim Yok
Tarih
2005
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: We investigated the relationship between insulin resistance and serum osteoprotegerin (OPG) levels in healthy obese subjects and healthy lean controls. Methods: Fifty obese subjects (age: 31 +/- 8 years) and 24 lean controls (age: 30 7 years) were included in the study. We used the homeostasis model assessment for insulin resistance (HOMA-IR) index as the index of insulin resistance. OPG levels were measured with the commercial ELISA kit. Obese subjects were studied in three groups: Group I (n = 25) HOMA-IR index < 2.24, Group II (n = 13) index 2.24-3.59, Group III (n = 12) index > 3.59. Group IV (n = 24) was the lean controls with HOMA-IR index < 2.24. Results: Obese subjects with increased insulin resistance (Group III) had lower OPG values than other groups (11.88 +/- 7.43 pg/ ml, 16.39 +/- 6.39 pg/ml, 17.37 +/- 9.61 pg/ml, and 18.1 +/- 6.65 pg/ml, respectively; Group I versus Group III p = 0.036; Group III versus Group IV p = 0.012). We also found significant inverse correlations between OPGc (corrected for BMI) and fasting glucose (r = -0.325, p = 0.005), fasting insulin (r = -0.404, p = 0.0001) as well as HOMA-IR (r = -0.428, p = 0.0001). Increased fibrinogen level was found in Group III than Group IV (9.32 +/- 1.97 mu mol/1 versus 7.47 +/- 1.65 mu mol/1, respectively; p = 0.005). In conclusion, insulin resistance in obesity is associated with decreased serum OPG levels and increased fibrinogen levels. The relationship between serum OPG levels and HOMA-IR may provide an insight into vascular endothelial dysfunction in obesity. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
Açıklama
13th European Congress on Obesity -- MAY 26-29, 2004 -- Prague, CZECH REPUBLIC
Anahtar Kelimeler
Obesity, Insulin Resistance, Osteoprotegerin, Atherosclerosis, Endothelial Dysfunction, Nf-Kappa-B, Homeostasis Model Assessment, Type-2 Diabetic-Patients, Receptor Activator, Rank Ligand, Atherosclerosis, Calcification
Kaynak
Diabetes Research And Clinical Practice
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
68
Sayı
3
