Castleman Disease: A Multicenter Case Series from Turkey

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dc.authoridÖzcan, Alper/0000-0002-6100-1205
dc.authoridkartal, ibrahim/0000-0002-2772-9956
dc.authoridmaral, senem/0000-0003-4766-1861
dc.authoridPaydas, Semra/0000-0003-4642-3693
dc.authoridOzdemir, Gul Nihal/0000-0002-3204-4353
dc.authoridELVERDI, TUGRUL/0000-0001-9496-5353
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authorwosidGUVEN, ZEYNEP/HPH-8638-2023
dc.authorwosidÖzcan, Alper/GSE-7300-2022
dc.authorwosidkartal, ibrahim/AAA-5354-2021
dc.authorwosidmaral, senem/AAH-9926-2021
dc.authorwosidPaydas, Semra/F-3132-2018
dc.authorwosidAkgun Cagliyan, Gulsum/AAA-5330-2022
dc.authorwosidayhan, Aylin canbolat/JTT-7217-2023
dc.contributor.authorGunduz, Eren
dc.contributor.authorKirkizlar, Hakki Onur
dc.contributor.authorUmit, Elif Gulsum
dc.contributor.authorGulsaran, Sedanur Karaman
dc.contributor.authorOzkocaman, Vildan
dc.contributor.authorOzkalemkas, Fahir
dc.contributor.authorCandar, Omer
dc.date.accessioned2024-06-12T10:55:56Z
dc.date.available2024-06-12T10:55:56Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved. The aim of this multicenter study was to evaluate all cases of CD identified to date in Turkey to set up a national registry to improve the early recognition, treatment, and follow-up of CD. Materials and Methods: Both adult (n=130) and pediatric (n=10) patients with lymph node or involved field biopsy results reported as CD were included in the study. Patients' demographic information, clinical and laboratory characteristics, imaging study results, treatment strategies, and clinical outcomes were evaluated retrospectively. Results: A total of 140 patients (69 male and 71 female) with a diagnosis of UCD (n=73) or MCD (n=67) were included. The mean age was 39 years in the UCD group and 47 years in the MCD group. Female patients were more common in the UCD group. The most common histological subtype was hyaline vascular for both UCD and MCD patients. Asymptomatic patients were more common in the UCD group. Anemia, elevations of acute phase reactants, and hypoalbuminemia were more common in the MCD group. The most commonly used treatment strategies for UCD were surgical excision, rituximab, and radiotherapy, respectively. All UCD patients were alive at a median of 19.5 months of follow-up. The most commonly used treatment strategies for MCD were methyl prednisolone, R-CHOP, R-CVP, and rituximab. Thirteen MCD patients had died at a median of 34 months of follow-up. Conclusion: This study is important in presenting the patient characteristics and treatment strategies for CD from Turkey, with the potential of increasing awareness about CD. Treatment data may help in making decisions, particularly in countries that do not have access to siltuximab. However, larger prospective studies are needed to make definitive conclusions.en_US
dc.description.sponsorshipTurkish Society of Hematologyen_US
dc.description.sponsorshipThe database project of this study was supported by the Turkish Society of Hematology.en_US
dc.identifier.doi10.4274/tjh.galenos.2022.2021.0670
dc.identifier.endpage135en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue2en_US
dc.identifier.pmid35176839en_US
dc.identifier.scopus2-s2.0-85131226359en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage130en_US
dc.identifier.trdizinid515131en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2022.2021.0670
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/515131
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19590
dc.identifier.volume39en_US
dc.identifier.wosWOS:000810203000006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal Of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCastleman Diseaseen_US
dc.subjectUnicentricen_US
dc.subjectMulticentricen_US
dc.subjectTreatmenten_US
dc.subjectLymph-Node Hyperplasiaen_US
dc.titleCastleman Disease: A Multicenter Case Series from Turkeyen_US
dc.typeArticleen_US

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