7?,8?-Dihydroobolactone, a typanocidal ?-pyrone from the rainforest tree Cryptocarya obovata

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dc.authoridAvery, Vicky M/0000-0003-4914-2299
dc.authoridQuinn, Ronald J/0000-0002-4022-2623
dc.authoridSykes, Melissa/0000-0002-9379-9012
dc.authoridDavis, Rohan A./0000-0003-4291-7573
dc.authorwosidAvery, Vicky M/A-5449-2010
dc.authorwosidQuinn, Ronald J/A-7931-2008
dc.authorwosidSykes, Melissa/M-1149-2017
dc.authorwosidDavis, Rohan A./B-1689-2008
dc.contributor.authorDavis, Rohan A.
dc.contributor.authorDemirkiran, Ozlem
dc.contributor.authorSykes, Melissa L.
dc.contributor.authorAvery, Vicky M.
dc.contributor.authorSuraweera, Lekha
dc.contributor.authorFechner, Gregory A.
dc.contributor.authorQuinn, Ronald J.
dc.date.accessioned2024-06-12T10:50:12Z
dc.date.available2024-06-12T10:50:12Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone ( 1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 mu M. (C) 2010 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipDrugs for Neglected Disease initiative (DNDi); Deutsche Gesellschaft fur Technische Zusammenarbeit GmbH, Government of the Federal Republic of Germany; Endeavour Foundation of Australiaen_US
dc.description.sponsorshipFinancial support from Drugs for Neglected Disease initiative (DNDi) and Deutsche Gesellschaft fur Technische Zusammenarbeit GmbH on behalf of the Government of the Federal Republic of Germany is acknowledged. One of the authors (O. Demirkiran) is grateful to the Endeavour Foundation of Australia for a fellowship that enabled her to conduct research at the Eskitis Institute. We thank Dr. H. Vu from Griffith University for HRESIMS measurements. The authors thank Dr. D. Camp, C. Lewis and K. Watts from the Molecular Libraries group, Griffith University for their assistance in the preparation of the screening library. We are also indebted to P. Forster and G. Guymer of the Queensland Herbarium for collection and identification of the plant material. The authors thank Dr. A. Schnaufer (University of Edinburgh) who kindly supplied the trypanosome cell stock. We are thankful to B. Aldred and R. Lang from Discovery Biology, Eskitis Institute for maintenance and supply of cancer cell lines.en_US
dc.identifier.doi10.1016/j.bmcl.2010.05.091
dc.identifier.endpage4059en_US
dc.identifier.issn0960-894X
dc.identifier.issue14en_US
dc.identifier.pmid20558060en_US
dc.identifier.scopus2-s2.0-77953871828en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4057en_US
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2010.05.091
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17912
dc.identifier.volume20en_US
dc.identifier.wosWOS:000279258800013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject7 ',8 '-Dihydroobolactoneen_US
dc.subjectCryptocarya Obovataen_US
dc.subjectAntitrypanosomalen_US
dc.subjectTrypanosoma Brucei Bruceien_US
dc.subjectMCF-7en_US
dc.subjectA549en_US
dc.subjectHelaen_US
dc.subjectHEK293en_US
dc.subjectTrypanosoma-Bruceien_US
dc.subjectFlavonoidsen_US
dc.subjectAlkaloidsen_US
dc.subjectDrugen_US
dc.title7?,8?-Dihydroobolactone, a typanocidal ?-pyrone from the rainforest tree Cryptocarya obovataen_US
dc.typeArticleen_US

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