7?,8?-Dihydroobolactone, a typanocidal ?-pyrone from the rainforest tree Cryptocarya obovata
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone ( 1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 mu M. (C) 2010 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
7 ',8 '-Dihydroobolactone, Cryptocarya Obovata, Antitrypanosomal, Trypanosoma Brucei Brucei, MCF-7, A549, Hela, HEK293, Trypanosoma-Brucei, Flavonoids, Alkaloids, Drug
Kaynak
Bioorganic & Medicinal Chemistry Letters
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
20
Sayı
14
