Synthesis, Antimicrobial and Cytotoxic Activity Studies of Some New Benzoxazole Derivatives

Basit Öğe Kaydı
dc.contributor.authorErol, Meryem
dc.contributor.authorÇelik, İsmail
dc.contributor.authorKuyucuklu, Gülcan
dc.contributor.authorUzunhisarcıklı, Ebru
dc.date.accessioned2024-06-12T10:05:02Z
dc.date.available2024-06-12T10:05:02Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThere is an urgent need to develop new antimicrobial drugs due to the rapid development of resistance to increasing microbial infectious diseases and drugs used in their treatment. Also, the compounds synthesized for use in cancer treatment limit their use due to their cytotoxic effect on normal cells and cancerous cells, and their side effects are high. For this reason, researches continue to intensify the drugs developed for cancer treatment to be selectively effective on cancer cells and to reduce their side effects as much as possible. Within this study's scope, 7 compounds of 2-(p-substituted phenyl)-5-(2-substitutedacetamido) were synthesized in 3 steps, and their structures were illuminated by HRMS, 1H-NMR, and 13C-NMR spectroscopy methods. Their antimicrobial activities were evaluated on 10 different microorganisms. In addition, cytotoxic activities were investigated on MCF-7 and A549 cell lines by the MTT method. As a result of the study, it was determined that the synthesized compounds were both antibacterial and antifungal at MIC values ranging from 64-256 ?g/mL, and compound 9 had significant cytotoxic activity on both A549 and MCF-7. The results obtained will make an important contribution to the studies conducted to develop new or alternative antimicrobial and cytotoxic agents.en_US
dc.identifier.doi10.31590/ejosat.822417
dc.identifier.endpage462en_US
dc.identifier.issn2148-2683
dc.identifier.issue21en_US
dc.identifier.startpage455en_US
dc.identifier.trdizinid1175233en_US]
dc.identifier.urihttps://doi.org/10.31590/ejosat.822417
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1175233
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13198
dc.identifier.volume0en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofAvrupa Bilim ve Teknoloji Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSynthesis, Antimicrobial and Cytotoxic Activity Studies of Some New Benzoxazole Derivativesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu