Synthesis, Antimicrobial and Cytotoxic Activity Studies of Some New Benzoxazole Derivatives
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Tarih
2021
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info:eu-repo/semantics/openAccess
Özet
There is an urgent need to develop new antimicrobial drugs due to the rapid development of resistance to increasing microbial infectious diseases and drugs used in their treatment. Also, the compounds synthesized for use in cancer treatment limit their use due to their cytotoxic effect on normal cells and cancerous cells, and their side effects are high. For this reason, researches continue to intensify the drugs developed for cancer treatment to be selectively effective on cancer cells and to reduce their side effects as much as possible. Within this study's scope, 7 compounds of 2-(p-substituted phenyl)-5-(2-substitutedacetamido) were synthesized in 3 steps, and their structures were illuminated by HRMS, 1H-NMR, and 13C-NMR spectroscopy methods. Their antimicrobial activities were evaluated on 10 different microorganisms. In addition, cytotoxic activities were investigated on MCF-7 and A549 cell lines by the MTT method. As a result of the study, it was determined that the synthesized compounds were both antibacterial and antifungal at MIC values ranging from 64-256 ?g/mL, and compound 9 had significant cytotoxic activity on both A549 and MCF-7. The results obtained will make an important contribution to the studies conducted to develop new or alternative antimicrobial and cytotoxic agents.
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Avrupa Bilim ve Teknoloji Dergisi
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0
Sayı
21
