Long-term prognostic significance of pentraxin-3 in patients with acute myocardial infarction: 5-year prospective cohort study

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dc.authoridözpamuk karadeniz, fatma/0000-0001-5839-9104
dc.authoridEren, Mehmet/0000-0002-5570-705X
dc.authoridAltay, Servet/0000-0001-7112-3970
dc.authorwosidCan, Günay/AAB-1669-2020
dc.authorwosidözpamuk karadeniz, fatma/AAC-9156-2022
dc.authorwosidEren, Mehmet/ACD-8031-2022
dc.authorwosidAltay, Servet/C-1387-2018
dc.contributor.authorAltay, Servet
dc.contributor.authorCakmak, Huseyin Altug
dc.contributor.authorOz, Tugba Kemaloglu
dc.contributor.authorKaradeniz, Fatma Ozpamuk
dc.contributor.authorTurer, Ayca
dc.contributor.authorErer, Hatice Betul
dc.contributor.authorKilic, Gulen Feyzan
dc.date.accessioned2024-06-12T11:12:17Z
dc.date.available2024-06-12T11:12:17Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: A predictive role of serum Pentraxin 3 (PTX3) for short-term adverse cardiovascular events including mortality in acute myocardial infarction (AMI) was reported in recent studies. The aim of the study was to investigate long-term prognostic significance of serum PTX3 in an AMI with 5-year follow-up period in this study. Methods: In this prospective study, 140 patients, who were admitted to the emergency department between January 2011 and December 2011 with acute chest pain and/or dyspnea and diagnosed with AMI and 60 healthy controls were included. PTX3 levels were measured at admission by using an ELISA method. The study group was divided into tertiles on the basis of admission PTX3 values: the high-PTX3 group (>= 4.27 ng/mL), the middle-PTX3 groups (4.27-1.63 ng/mL), and the low-PTX3 group (>= 1.63 ng/mL). Results: PTX3 level was significantly more greatly increased in the AMI group than in the controls (2.27 +/- 0.81 vs. 0.86 +/- 0.50 ng/mL, p<0.001). PTX3 level was found to be significantly positively correlated with TIMI score (r=0.368, p=0.037), high sensitive C-reactive protein (hsCRP) (r=0.452, p=0.024), pro-BNP (r=0.386, p=0.029), troponin I (r=0.417, p=<0.001), and GRACE score (r=0.355, p=0.045), and negatively correlated with HDL cholesterol (r=-0.203, p=0.016) and LVEF (r=-0.345, p=0.028). In multivariate analysis, PTX3 (OR=1.12, 95% CI 1.04-1.20; p=0.001) was a significant independent predictor of long-term cardiovascular mortality, after adjusting for other risk factors. Conclusion: PTX3 is a novel biomarker that may help to identify high risk individuals with AMI, who are potentially at risk of early major adverse cardiovascular events including mortality in the long-term period.en_US
dc.identifier.doi10.14744/AnatolJCardiol.2016.7307
dc.identifier.endpage209en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue3en_US
dc.identifier.pmid27488759en_US
dc.identifier.scopus2-s2.0-85015269461en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage202en_US
dc.identifier.trdizinid256953en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2016.7307
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/256953
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23092
dc.identifier.volume17en_US
dc.identifier.wosWOS:000400655700007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPentraxin-3en_US
dc.subjectAcute Myocardial Infarctionen_US
dc.subjectLong-Term Prognosisen_US
dc.subjectMortalityen_US
dc.subjectCardiovascular Eventen_US
dc.subjectHeart-Failureen_US
dc.subjectPtx3en_US
dc.subjectInflammationen_US
dc.subjectMortalityen_US
dc.subjectDiseaseen_US
dc.subjectMarkersen_US
dc.subjectEventsen_US
dc.titleLong-term prognostic significance of pentraxin-3 in patients with acute myocardial infarction: 5-year prospective cohort studyen_US
dc.typeArticleen_US

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