Radiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systems

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dc.authorwosidERDOĞAN, Sevil/B-5800-2015
dc.authorwosidTaşdelen, Betül/ABA-6295-2020
dc.authorwosidFerreira, Fernando/JZT-4995-2024
dc.contributor.authorTasdelen, Betul
dc.contributor.authorErdogan, Sevil
dc.contributor.authorBekar, Bahadir
dc.date.accessioned2024-06-12T11:03:26Z
dc.date.available2024-06-12T11:03:26Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description14th International Conference on Nanosciences and Nanotechnologies (NN) -- JUL 04-07, 2017 -- Thessaloniki, GREECEen_US
dc.description.abstractIn this work, a new chitosan (CS)/hyaluronic acid (HA)/hydroxyapatite (HAP) hydrogels were synthesized by using gamma rays irradiation technique for oral delivery of drugs. The hydrogelss were characterized using fourier transform infrared spectroscopy (FTIR) and the physicochemical properties of shrimp chitosan was determined with both FTIR and scanning electron microscopy (SEM). The use of the hydrogel samples as a drug delivery system was investigated by an anticancer drug. 5-Fluorouracil (5-FU) was used as a model anticancer drug to investigate the drug uptake and release kinetics of hydrogels. The properties of the hydrogels were evaluated in terms of swelling, drug uptake and release behaviours. The addition of hyaluronic acid and hydroxyapatite in the gel structure improved drug uptake and release capability of the new hydrogels. (c) 2018 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of 14th International Conference on Nanosciences & Nanotechnologies (NN17).en_US
dc.description.sponsorshipNamik Kemal University Scientific Research Project [NKUBAP.00.17.AR.14.14]en_US
dc.description.sponsorshipThe authors acknowledge Namik Kemal University Scientific Research Project (NKUBAP.00.17.AR.14.14) for funding.en_US
dc.identifier.doi10.1016/j.matpr.2018.05.043
dc.identifier.endpage15997en_US
dc.identifier.issn2214-7853
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85056511434en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15990en_US
dc.identifier.urihttps://doi.org/10.1016/j.matpr.2018.05.043
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21665
dc.identifier.volume5en_US
dc.identifier.wosWOS:000441006800006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMaterials Today-Proceedingsen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHydrogelsen_US
dc.subjectChitosanen_US
dc.subjectHyaluronic Aciden_US
dc.subjectHydroxiapatiteen_US
dc.subjectDrug Deliveryen_US
dc.subjectPhysicochemical Characterizationen_US
dc.subjectHydroxyapatite Nanoparticlesen_US
dc.subjectPharmaceutical Applicationsen_US
dc.subjectChitosanen_US
dc.subjectChitinen_US
dc.subjectLiveren_US
dc.titleRadiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systemsen_US
dc.typeConference Objecten_US

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