Radiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systems
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this work, a new chitosan (CS)/hyaluronic acid (HA)/hydroxyapatite (HAP) hydrogels were synthesized by using gamma rays irradiation technique for oral delivery of drugs. The hydrogelss were characterized using fourier transform infrared spectroscopy (FTIR) and the physicochemical properties of shrimp chitosan was determined with both FTIR and scanning electron microscopy (SEM). The use of the hydrogel samples as a drug delivery system was investigated by an anticancer drug. 5-Fluorouracil (5-FU) was used as a model anticancer drug to investigate the drug uptake and release kinetics of hydrogels. The properties of the hydrogels were evaluated in terms of swelling, drug uptake and release behaviours. The addition of hyaluronic acid and hydroxyapatite in the gel structure improved drug uptake and release capability of the new hydrogels. (c) 2018 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of 14th International Conference on Nanosciences & Nanotechnologies (NN17).
Açıklama
14th International Conference on Nanosciences and Nanotechnologies (NN) -- JUL 04-07, 2017 -- Thessaloniki, GREECE
Anahtar Kelimeler
Hydrogels, Chitosan, Hyaluronic Acid, Hydroxiapatite, Drug Delivery, Physicochemical Characterization, Hydroxyapatite Nanoparticles, Pharmaceutical Applications, Chitosan, Chitin, Liver
Kaynak
Materials Today-Proceedings
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
5
Sayı
8
