Blood pressure, autonomic stress, and inflammatory markers during sleep deprivation and recovery in healthy men

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authorid, erdogan/0000-0003-2036-6870
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidZorkun, Cafer/S-7132-2016
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorBozer, Ozge
dc.contributor.authorKaya, Oktay
dc.contributor.authorOzturk, Gulnur
dc.contributor.authorBulut, Erdogan
dc.contributor.authorZorkun, Cafer
dc.contributor.authorOzturk, Levent
dc.date.accessioned2024-06-12T10:56:00Z
dc.date.available2024-06-12T10:56:00Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Recent community-based studies have identified sleep deprivation (SD) as an important modifiable risk factor for hypertension However, the underlying mechanisms linking SD to hypertension remain elusive. Thus, this study investigates blood pressure (BP) responses to cardiac autonomic stress tests in the presence of SD. Furthermore, we analyzed vascular inflammatory biomarkers as a possible underlying factor linking SD to increased BP. Methods: Ten healthy male volunteers (age, 21.6 +/- 1.2 years) underwent repeated autonomic stress tests for three consecutive days (baseline, SD, and recovery). The autonomic stress tests included the Valsalva maneuver, mental arithmetic, isometric handgrip, and cold pressor tests. Each day, resting BPs were measured, venous blood samples were collected for intercellular adhesion molecule 1, vascular cell adhesion molecule 1, and E-selectin measurements, and stress tests were performed between 0900 and 1100. Ambulatory BP was recorded during the entire SD period (24 h). Results: One-night SD abolished BP reactivity to the Valsalva maneuver, isometric hand grip, and cold pressor tests, which returned after recovery sleep. Ambulatory BP monitoring showed that the mean systolic and diastolic BPs were 121.1 +/- 8.5 mm Hg and 72.8 +/- 6.3 mm Hg, respectively, between 0700 and 2300 and 120.3 +/- 9.6 mm Hg and 74.1 +/- 6.1 mm Hg, respectively, between 2300 and 0700 during the SD day (p>0.05 for both). Vascular inflammatory markers seemed unrelated to BP changes. Conclusion: Acute SD altered BP responses to cardiac autonomic stress tests in healthy men without affecting resting BP levels. SD led to a non-dipping pattern in BP oscillation. Collectively, these findings highlight the importance of sleep in regulating BP.en_US
dc.description.sponsorshipTrakya University Scientific Research Projects [TUBAP 2018-03]en_US
dc.description.sponsorshipThis study was financially supported by Trakya University Scientific Research Projects (TUBAP 2018-03).en_US
dc.identifier.doi10.14744/AnatolJCardiol.2020.42205
dc.identifier.endpage413en_US
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue6en_US
dc.identifier.pmid34100728en_US
dc.identifier.scopus2-s2.0-85108020885en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage407en_US
dc.identifier.trdizinid487317en_US
dc.identifier.urihttps://doi.org/10.14744/AnatolJCardiol.2020.42205
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/487317
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19632
dc.identifier.volume25en_US
dc.identifier.wosWOS:000662160500007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofAnatolian Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell Adhesion Moleculesen_US
dc.subjectStress Testsen_US
dc.subjectE-Selectinen_US
dc.subjectSleep Lossen_US
dc.subjectValsalva Maneuveren_US
dc.subjectCardiovascular Reactivityen_US
dc.subjectRisk-Factoren_US
dc.subjectDurationen_US
dc.subjectHypertensionen_US
dc.subjectMetaanalysisen_US
dc.subjectVariabilityen_US
dc.subjectHumansen_US
dc.titleBlood pressure, autonomic stress, and inflammatory markers during sleep deprivation and recovery in healthy menen_US
dc.typeArticleen_US

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