Intrahepatic Cholestasis and Adverse Perinatal Outcomes in the Third Trimester: A 10-year Case-control Study

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dc.contributor.authorYener, Cem
dc.contributor.authorSayın, Cenk
dc.contributor.authorErbilen, Esra Altan
dc.contributor.authorAteş, Sinan
dc.contributor.authorVarol, Füsun
dc.date.accessioned2024-06-12T10:05:20Z
dc.date.available2024-06-12T10:05:20Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: To evaluate the perinatal outcomes in women whom developed intrahepatic cholestasis of pregnancy (ICP). Materials and Methods: Medical records of 76 patients who were followed up in a tertiary center due to ICP between January 2010 and December 2019 were evaluated retrospectively. Women with ICP (n=76) and age matched controls (n=228) were included to our study. Bile acid (BA) values could be reached in 42 of 76 patients. Results: There was no significant difference in terms of family history, fetal gender, or the presence of meconium in the amniotic fluid between the groups (p>0.05) except cesarean rates were significantly higher in ICP group (p<0.001). The median gestational weeks at delivery, fetal weight and Apgar scores at the 1st- and at the 5th-minutes in the ICP group were significantly lower than those in the controls (p<0.05). Gestational weeks at delivery was similar in women with BA values above or under 40 ?mol/L (p>0.05). Conclusion: ICP has important fetal implications. There is an increased risk for poor fetal outcomes, including preterm delivery and fetal demise. Therefore, close follow-up and meticulous observation is indispensable. Keywords: Intrahepatic cholestasis, neonatal outcome, pregnancy, ursodesoxycholic aciden_US
dc.identifier.doi10.4274/hamidiyemedj.galenos.2022.27247
dc.identifier.endpage45en_US
dc.identifier.issn2718-0956
dc.identifier.issue1en_US
dc.identifier.startpage40en_US
dc.identifier.trdizinid519859en_US]
dc.identifier.urihttps://doi.org/10.4274/hamidiyemedj.galenos.2022.27247
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/519859
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13384
dc.identifier.volume3en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofHamidiye Medical Journalen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleIntrahepatic Cholestasis and Adverse Perinatal Outcomes in the Third Trimester: A 10-year Case-control Studyen_US
dc.typeArticleen_US

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