Intrahepatic Cholestasis and Adverse Perinatal Outcomes in the Third Trimester: A 10-year Case-control Study
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Tarih
2022
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: To evaluate the perinatal outcomes in women whom developed intrahepatic cholestasis of pregnancy (ICP). Materials and Methods: Medical records of 76 patients who were followed up in a tertiary center due to ICP between January 2010 and December 2019 were evaluated retrospectively. Women with ICP (n=76) and age matched controls (n=228) were included to our study. Bile acid (BA) values could be reached in 42 of 76 patients. Results: There was no significant difference in terms of family history, fetal gender, or the presence of meconium in the amniotic fluid between the groups (p>0.05) except cesarean rates were significantly higher in ICP group (p<0.001). The median gestational weeks at delivery, fetal weight and Apgar scores at the 1st- and at the 5th-minutes in the ICP group were significantly lower than those in the controls (p<0.05). Gestational weeks at delivery was similar in women with BA values above or under 40 ?mol/L (p>0.05). Conclusion: ICP has important fetal implications. There is an increased risk for poor fetal outcomes, including preterm delivery and fetal demise. Therefore, close follow-up and meticulous observation is indispensable. Keywords: Intrahepatic cholestasis, neonatal outcome, pregnancy, ursodesoxycholic acid
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Kaynak
Hamidiye Medical Journal
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Scopus Q Değeri
Cilt
3
Sayı
1
