Tularemia seroprevalence in humans in the region of the Hittite-Arzawa War (Inner Aegean Region), where the fiirst biological weapon was used 3300 years ago

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dc.authorwosidGürcan, Şaban/D-2754-2017
dc.contributor.authorDavarci, Ismail
dc.contributor.authorEryildiz, Canan
dc.contributor.authorRenders, Duygu Percin
dc.contributor.authorBerberoglu, Ufuk
dc.contributor.authorGurcan, Saban
dc.date.accessioned2024-06-12T10:54:39Z
dc.date.available2024-06-12T10:54:39Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: According to Egyptian records, tularemia emerged in the Canaan region, where it was first identified and spread to Anatolia over the Euphrates. It was used as an active biological weapon for the first time in the Hittite-Arzawa War in 1320-1318 BC. This study aimed to investigate the seroprevalence of tularemia in the Inner Aegean Region, which is thought to be the region where this war was fought 3300 years ago.Materials and methods: Tularemia seropositivity in humans was investigated in 27 villages/neighborhoods in 3 districts in each of Manisa, Kiltahya, and Usak provinces. Before the study, the participants were informed about the disease via posters, and their blood samples were taken following filling out the questionnaire. Microagglutination tests were performed using in-house tularemia antigen and V plate for serological experiments. Rose-Bengal test was also performed on seropositive sera.Results: Of the total of 410 people, 226 (55.12%) were male. The mean age of the volunteers was 43.72 years. The highest participation was from Kiltahya Province. According to the results of the tularemia microagglutination test, seropositivity was detected in 6 cases. It was determined that all of the seropositive volunteers were in Kiltahya. When the tularemia antibody titers were examined, seropositivity was determined at 1/20-1/160 titers. No positivity was detected in the Rose-Bengal test for cross-reaction.Conclusion: Kiltahya has been identified as a risky region in terms of tularemia in the Inner Aegean Region. In order to use the resources in the country economically, first of all, the risk areas in terms of tularemia should be determined by serological studies in all regions. In order to increase awareness about the disease, physicians and filiation teams should be trained in risky areas. Surveillance studies should be conducted to identify and monitor possible sources in areas identified as risky.en_US
dc.identifier.doi10.55730/1300-0144.5586
dc.identifier.endpage315en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid36945928en_US
dc.identifier.scopus2-s2.0-85149145452en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage310en_US
dc.identifier.trdizinid1160983en_US
dc.identifier.urihttps://doi.org/10.55730/1300-0144.5586
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1160983
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19128
dc.identifier.volume53en_US
dc.identifier.wosWOS:000941667500036en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiological Warfare Agentsen_US
dc.subjectFrancisella Tularensisen_US
dc.subjectSeroepidemiological Studiesen_US
dc.subjectTularemiaen_US
dc.subjectTurkeyen_US
dc.titleTularemia seroprevalence in humans in the region of the Hittite-Arzawa War (Inner Aegean Region), where the fiirst biological weapon was used 3300 years agoen_US
dc.typeArticleen_US

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