The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock

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dc.contributor.authorMemis, Dilek
dc.contributor.authorInal, Mehmet Turan
dc.contributor.authorSut, Necdet
dc.date.accessioned2024-06-12T11:03:47Z
dc.date.available2024-06-12T11:03:47Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Septic shock is the leading causes of death in intensive care units. In addition to generous fluid administration, inotropic agents are commonly used to improve cardiac output. The effects of inotropic agents on regional blood flow remains unknown. Objective: The aim of this study was to assess the effects of levosimendan vs dobutamine added to dopamine on liver functions assessed using noninvasive liver function monitoring (LiMON) in patients with septic shock. Design: Prospective analysis. Measurements and results: We analyzed 30 patients with septic shock who were treated in an intensive care unit. Indocyanine green plasma disappearance rate (ICG-PDR) was conducted concurrently using the LiMON system. A dose of 0.3 mg/kg ICG was given through a cubital fossa vein as a bolus. Results: Statistical analysis showed that the variation of hemodynamic variables was different between groups. In our results, the increase in systolic blood pressure, diastolic blood pressure, and mean arterial pressure was significantly higher in levosimendan group than in dobutamine group (P < .05). There was a decrease in before-and after-infusion ICG-PDR values in dobutamine group (20.38 +/- 4.83 vs 20.34 +/- 5.30), and no statistical difference was detected (P = .649). There was an increase in before-and after-infusion ICG-PDR values in levosimendan group (18.70 +/- 2.59 vs 21.65 +/- 3.20), and a statistical difference was detected (P = .001). There was statistical difference between groups (P = .000). Conclusion: These results suggest that levosimendan added to dopamine improves systemic hemodynamics and increases splanchnic perfusion assessed using the user-friendly noninvasive bedside system LiMON in patients with septic shock compared with dobutamine. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipUniversity of Trakya [TUBAP 2008/122]en_US
dc.description.sponsorshipThis work was supported by the University of Trakya Research Grant No. TUBAP 2008/122.en_US
dc.identifier.doi10.1016/j.jcrc.2011.06.008
dc.identifier.issn0883-9441
dc.identifier.issn1557-8615
dc.identifier.issue3en_US
dc.identifier.pmid21855289en_US
dc.identifier.scopus2-s2.0-84861199740en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jcrc.2011.06.008
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21786
dc.identifier.volume27en_US
dc.identifier.wosWOS:000304872000028en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Critical Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIndocyanine Greenen_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectLevosimendanen_US
dc.subjectDobutamineen_US
dc.subjectSeptic Shocken_US
dc.subjectPlasma Disappearance Rateen_US
dc.subjectIndocyanine Greenen_US
dc.subjectTissue Perfusionen_US
dc.subjectOxygen Deliveryen_US
dc.subjectHeart-Failureen_US
dc.subjectSepsisen_US
dc.subjectDopexamineen_US
dc.subjectHemodynamicsen_US
dc.subjectEfficacyen_US
dc.titleThe effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shocken_US
dc.typeArticleen_US

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