The effects of levosimendan vs dobutamine added to dopamine on liver functions assessed with noninvasive liver function monitoring in patients with septic shock
Küçük Resim Yok
Tarih
2012
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Septic shock is the leading causes of death in intensive care units. In addition to generous fluid administration, inotropic agents are commonly used to improve cardiac output. The effects of inotropic agents on regional blood flow remains unknown. Objective: The aim of this study was to assess the effects of levosimendan vs dobutamine added to dopamine on liver functions assessed using noninvasive liver function monitoring (LiMON) in patients with septic shock. Design: Prospective analysis. Measurements and results: We analyzed 30 patients with septic shock who were treated in an intensive care unit. Indocyanine green plasma disappearance rate (ICG-PDR) was conducted concurrently using the LiMON system. A dose of 0.3 mg/kg ICG was given through a cubital fossa vein as a bolus. Results: Statistical analysis showed that the variation of hemodynamic variables was different between groups. In our results, the increase in systolic blood pressure, diastolic blood pressure, and mean arterial pressure was significantly higher in levosimendan group than in dobutamine group (P < .05). There was a decrease in before-and after-infusion ICG-PDR values in dobutamine group (20.38 +/- 4.83 vs 20.34 +/- 5.30), and no statistical difference was detected (P = .649). There was an increase in before-and after-infusion ICG-PDR values in levosimendan group (18.70 +/- 2.59 vs 21.65 +/- 3.20), and a statistical difference was detected (P = .001). There was statistical difference between groups (P = .000). Conclusion: These results suggest that levosimendan added to dopamine improves systemic hemodynamics and increases splanchnic perfusion assessed using the user-friendly noninvasive bedside system LiMON in patients with septic shock compared with dobutamine. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
Açıklama
Anahtar Kelimeler
Indocyanine Green, Plasma Disappearance Rate, Levosimendan, Dobutamine, Septic Shock, Plasma Disappearance Rate, Indocyanine Green, Tissue Perfusion, Oxygen Delivery, Heart-Failure, Sepsis, Dopexamine, Hemodynamics, Efficacy
Kaynak
Journal Of Critical Care
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
27
Sayı
3
