DNA methylation of the prestin gene and outer hair cell electromotile response of the cochlea in salicylate administration

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dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorid, erdogan/0000-0003-2036-6870
dc.authorwosidBudak, metin/Z-3010-2019
dc.authorwosidUZUN, CEM/K-3307-2012
dc.authorwosid, erdogan/C-4135-2015
dc.contributor.authorBulut, Erdogan
dc.contributor.authorBudak, Metin
dc.contributor.authorOzturk, Levent
dc.contributor.authorTurkmen, Mehmet T.
dc.contributor.authorUzun, Cem
dc.contributor.authorSipahi, Tammam
dc.date.accessioned2024-06-12T11:11:49Z
dc.date.available2024-06-12T11:11:49Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description36th Turkish National Meeting of the Otorhinolaryngology and Head and Neck Surgery -- NOV 05-09, 2014 -- Antalya, TURKEYen_US
dc.description.abstractBackground/aim: Activity of the prestin gene may have a role in the pathogenesis of salicylate-induced ototoxicity. We investigated DNA methylation for prestin gene exon 1 in salicylate-injected guinea pigs. Materials and methods: Fifteen guinea pigs (30 ears) underwent audiological evaluation including 1000 Hz probe-tone tympanometry and a distortion product otoacoustic emission (DPOAE) test. The animals were randomly divided into three groups. Groups 2 (8 ears) and 3 (14 ears) were injected with intramuscular saline and sodium salicylate (200 mg/kg), respectively twice daily for 2 weeks. Group 1 (8 ears) received no injection. DPOAE measurements were performed at baseline; after 1, 2, 4, and 8 h (acute effect); and after 1 and 2 weeks (chronic effect). After audiological measurements, the animals were sacrificed for DNA isolation. Results: While a significant decrease (P < 0.01) was found for the acute effect in all frequencies in Group 3 according to baseline measurements, there was no difference in terms of chronic effect. DNA methylation increased during the acute phase of salicylate administration, whereas it returned to initial levels during the chronic phase. Conclusion: Salicylate-induced changes in DPOAE responses may be related to prestin-gene methylation. These results may have important implications for salicylate ototoxicity.en_US
dc.description.sponsorshipTurkish Soc Otorhinolaryngol & Head Neck Surgen_US
dc.description.sponsorshipTUBAP-Trakya University Unit of Scientific Research Projects [2014/14]en_US
dc.description.sponsorshipThis study received financial support (TUBAP-Trakya University Unit of Scientific Research Projects-No: 2014/14).en_US
dc.identifier.doi10.3906/sag-1604-137
dc.identifier.endpage1633en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue5en_US
dc.identifier.pmid29152945en_US
dc.identifier.scopus2-s2.0-85034451068en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1626en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1604-137
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22945
dc.identifier.volume47en_US
dc.identifier.wosWOS:000414976900044en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtotoxicityen_US
dc.subjectTinnitusen_US
dc.subjectHair Cellsen_US
dc.subjectAuditoryen_US
dc.subjectOuteren_US
dc.subjectDistortion Product Otoacoustic Emissionen_US
dc.subjectSodium Salicylateen_US
dc.subjectDNA Methylationen_US
dc.subjectNon-Cpg Methylationen_US
dc.subjectAuditory-Perception Tinnitusen_US
dc.subjectEmbryonic Stem-Cellsen_US
dc.subjectMotor Proteinen_US
dc.subjectGuinea-Pigen_US
dc.subjectMechanismsen_US
dc.subjectExpressionen_US
dc.subjectAspirinen_US
dc.subjectRatsen_US
dc.titleDNA methylation of the prestin gene and outer hair cell electromotile response of the cochlea in salicylate administrationen_US
dc.typeConference Objecten_US

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