Beneficial Effects of Quercetin on the Zone of Stasis in an Experimental Burn Model

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dc.authoridOrhan, Abdullah Erkan/0000-0001-6532-5840
dc.authorid, ertan/0000-0002-3053-9133
dc.authorwosidOrhan, Abdullah Erkan/A-6237-2017
dc.authorwosidŞahin, Ertan/AAG-8999-2020
dc.contributor.authorOrhan, Erkan
dc.contributor.authorSahin, Ertan
dc.contributor.authorMetin, Melike Sapmaz
dc.contributor.authorTarladacalisir, Yeter Topcu
dc.date.accessioned2024-06-12T11:17:28Z
dc.date.available2024-06-12T11:17:28Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In burn injury, the zone of stasis determines the width and depth of the necrosis. Our aim is to show the effectiveness of quercetin on the viability within the zone of stasis in burns of rats. Materials and Methods: Forty-eight rats were divided into three groups. The rats in Group 1 (control group) were only applied the comb burn model; the rats in Group 2 (post-burn group) were administered 50 mg/kg of quercetin intraperitoneally, every day after the burn procedure until euthanasia; and the rats in Group 3 (pre-burn group) were administered 50 mg/kg of quercetin intraperitoneally, every day for 7 days before and after the burn procedure until euthanasia. Results: The living tissue calculated was 85.41% (+/- 14.06) in Group 3, 40.37% (+/- 9.75) in Group 2, and 16.81% (+/- 9.4) in Group 1. The level of apoptosis was 30.0 (+/- 10.8) in Group 3, 33.8 (+/- 08.7) in Group 2, and 37.4 (+/- 11.5) in Group 1. The level of autophagy was 49.50 (+/- 8.58) in Group 3, 27.17 (+/- 5.53) in Group 2, and 21.00 (+/- 5.66) in Group 1. All the differences between the groups were statistically significant (p< 0.01). Conclusion: Quercetin reduces apoptosis and increases autophagy, thereby increasing tissue viability in the zone of stasis of burn injury.en_US
dc.description.sponsorshipNamik Kemal University Research Center [NKUBAP.00.20.AR.15.01]en_US
dc.description.sponsorshipThe article was supported under project NKUBAP.00.20.AR.15.01 by the Namik Kemal University Research Center.en_US
dc.identifier.doi10.5152/etd.2017.0164
dc.identifier.endpage130en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85056575378en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage125en_US
dc.identifier.trdizinid305241en_US
dc.identifier.urihttps://doi.org/10.5152/etd.2017.0164
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/305241
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24716
dc.identifier.volume40en_US
dc.identifier.wosWOS:000446895400003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectZone Of Stasisen_US
dc.subjectQuercetinen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectReperfusion Injuryen_US
dc.subjectWound Progressionen_US
dc.subjectRatsen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectIschemiaen_US
dc.subjectCellsen_US
dc.subjectNecrosisen_US
dc.subjectTissueen_US
dc.subjectRolesen_US
dc.titleBeneficial Effects of Quercetin on the Zone of Stasis in an Experimental Burn Modelen_US
dc.typeArticleen_US

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