Expression of MicroRNA 146a, 155, 181 and 223 in febrile seizure

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dc.authoridDinleyici, Ener/0000-0002-0339-0134
dc.authoridGUL MERT, GULEN/0000-0002-1160-5617
dc.authoridYarar, Coskun/0000-0001-7462-4578
dc.authorwosidDinleyici, Ener/AAF-8688-2019
dc.authorwosidEkici, Arzu/AAK-7846-2020
dc.authorwosidGUL MERT, GULEN/J-4594-2018
dc.contributor.authorCarman, Kursat Bora
dc.contributor.authorKaral, Yasemin
dc.contributor.authorMert, Gul Gulen
dc.contributor.authorEkici, Arzu
dc.contributor.authorPerk, Peren
dc.contributor.authorArslantas, Didem
dc.contributor.authorYarar, Coskun
dc.date.accessioned2024-06-12T11:01:50Z
dc.date.available2024-06-12T11:01:50Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground. We studied microRNAs (miRNAs) -146a, -155, -181 and -223 expressions and proinflammatory cytokine levels in children with Febrile seizure (FS) and compared to febrile controls. Methods. This prospective multicenter study examined representative populations in eight different cities in Turkey between June 30, 2018 and July 1, 2019. Blood samples were taken from all children at presentation. The real time (RT) polymerase chain reaction (PCR) were used to measure the expressions of microRNAs and tumor necrosis factor alpha (TNF-a), interleukin 1 beta (IL-113), and interleukin 6 (IL-6) levels were studied by enzyme-linked immuno-sorbent assay. Results. The study was conducted with 60 children; 30 children with FS and 30 children in the febrile control group. The seizure was classified as simple FS in 73.3 % and half of the children were experiencing their first FS episode. Although the expression levels of miRNAs-146a, -181a and -155 were higher in febrile seizure patients, only miRNAs 146a level was significantly higher in FS patients. Serum TNF-alpha, IL-1 beta, IL-6 levels were higher in the FS group than the controls. The results of statistical analysis showed that there were correlations within miRNA expressions in children with FS. No differences were found considering miRNA expression between FS type, number of FS experienced. Conclusions. miRNAs-146a, -181a, -155 and -223 may be involved in FS pathogenesis. Altered miRNA expression levels might be an adaptive response to inflammation. New therapeutic approaches might be developed based on miRNA expressions in children with FS.en_US
dc.description.sponsorshipEskisehir Osmangazi Universityen_US
dc.description.sponsorshipThis study has been supported by a research grant from Eskisehir Osmangazi University (2019) .en_US
dc.identifier.doi10.24953/turkjped.2021.04.006
dc.identifier.endpage601en_US
dc.identifier.issn0041-4301
dc.identifier.issue4en_US
dc.identifier.pmid34449141en_US
dc.identifier.scopus2-s2.0-85114106278en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage594en_US
dc.identifier.trdizinid509421en_US
dc.identifier.urihttps://doi.org/10.24953/turkjped.2021.04.006
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/509421
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21045
dc.identifier.volume63en_US
dc.identifier.wosWOS:000691556600005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish J Pediatricsen_US
dc.relation.ispartofTurkish Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFebrile Seizureen_US
dc.subjectMicrornaen_US
dc.subjectProinflammatory Cytokineen_US
dc.subjectImmature Rat Modelen_US
dc.subjectInflammationen_US
dc.subjectChildrenen_US
dc.subjectPcren_US
dc.titleExpression of MicroRNA 146a, 155, 181 and 223 in febrile seizureen_US
dc.typeArticleen_US

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