The Frequency of anti-CCP antibodies in patients with rheumatoid arthritis and psoriatic arthritis and their relationship with clinical features and parameters of angiogenesis: A comparative study

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dc.authorwosidCakir, Necati/AAG-7283-2019
dc.contributor.authorEker, Yeliz Ozkaya
dc.contributor.authorPamuk, Omer Nuri
dc.contributor.authorPamuk, Gulsum Emel
dc.contributor.authorDonmez, Salim
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T11:13:39Z
dc.date.available2024-06-12T11:13:39Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Macrophage migration inhibitory factor (MIF) and vascular endothelial growth factor (VEGF), as crucial parameters of angiogenesis and inflammation, were evaluated to identify the role of cyclic citrullinated peptide antibodies (anti-CCP) during angiogenesis in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Material and Methods: A total of 145 patients with RA, 44 patients with PsA, and 73 healthy subjects were included in this study. The clinical features, total blood counts, and acute phase parameters of RA and PsA patients were recorded. Anti-CCP antibody, VEGF, and MIF levels were determined with enzyme-linked immunosorbent assay (ELISA). Results: Anti-CCP positivity was significantly higher in the RA group (69%) than in both PsA (20.6%) and controls (8.2%) (p values<0.001). There was no difference between anti-CCP-positive and-negative RA patients regarding the extra-articular manifestations (p>0.05). VEGF and MIF levels were similar in anti-CCP-positive and-negative RA patients (all p values>0.05). The specificity of anti-CCP antibodies for RA was found to be 87.2%. No relationship was found between anti-CCP antibody positivity and clinical features, disease activity, functional disability as assessed by health assessment questionnaire scores, and extra-articular manifestations. There was no relationship between parameters of angiogenesis and anti-CCP antibody positivity. Both RF and anti-CCP antibodies were observed to be positive in most patients with RA. Conclusion: Either RF or anti-CCP antibody was positive in a considerable proportion of our RA patients. Therefore, anti-CCP antibodies are important in the diagnosis of RF-negative patients who present with clinical findings of RA.en_US
dc.description.sponsorshipuniversity's Scientific Research Foundationen_US
dc.description.sponsorshipThis Project was supported by our university's Scientific Research Foundation. We thank our university's Microbiology Department for laboratory support.en_US
dc.identifier.doi10.5152/eurjrheumatol.2014.022
dc.identifier.endpage71en_US
dc.identifier.issn2147-9720
dc.identifier.issn2148-4279
dc.identifier.issue2en_US
dc.identifier.pmid27708878en_US
dc.identifier.startpage67en_US
dc.identifier.trdizinid231095en_US
dc.identifier.urihttps://doi.org/10.5152/eurjrheumatol.2014.022
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/231095
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23635
dc.identifier.volume1en_US
dc.identifier.wosWOS:000218657100006en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofEuropean Journal Of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectAnti-Cyclic Citrullinated Peptide Antibodiesen_US
dc.subjectAngiogenesisen_US
dc.titleThe Frequency of anti-CCP antibodies in patients with rheumatoid arthritis and psoriatic arthritis and their relationship with clinical features and parameters of angiogenesis: A comparative studyen_US
dc.typeArticleen_US

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