Protective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusion

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authoridUz, Yesim/0000-0002-0381-4590
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorInan, Mustafa
dc.contributor.authorUz, Yesim Hulya
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorTopcu-Tarladacalisir, Yeter
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorAkpolat, Meryem
dc.contributor.authorAydogdu, Nurettin
dc.date.accessioned2024-06-12T11:14:09Z
dc.date.available2024-06-12T11:14:09Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study evaluated the protective effect of sildenafil on liver injury induced by intestinal ischemia-reperfusion. Methods: Forty female Sprague Dawley rats were divided into 4 groups: sham-control (SC), ischemia (I), ischemia-reperfusion (IR), and ischemia-reperfusion+ sildenafil (SIL; sildenafil gavaged at 50 mg/kg before operating). A 2-h ischemia-reperfusion was performed by clamping the superior mesenteric artery. Liver function, plasma alanine (ALT) and aspartate (AST) aminotransferase, and intestinal and liver malondialdehyde (MDA) were measured at the end of the experiment. Intestinal and liver tissue damage was examined by histology. Liver samples were immunologically stained for endothelial nitric oxide synthase (eNOS) and proliferating cell nuclear antigen (PCNA). Results: The ALT and AST levels were highest in the IR group and were lower in the SIL group (p<0.05). Intestinal MDA levels were statistically higher in the IR group than in the SC, I and SIL groups. Liver MDA levels were significantly higher in the IR group than in the I and SC groups (p<0.05) and higher than in the SIL group (p>0.05). Intestinal damage based on Chiu scoring was more severe in the IR than in the SIL group (p<0.05). Sildenafil reduced damage and also increased eNOS and PCNA immunoreactivity in liver tissue. Conclusions: Sildenafil shows a protective effect on intestinal ischemia-reperfusion-induced liver injury, possibly by decreasing vascular resistance through increased nitric oxide levels. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jpedsurg.2012.12.054
dc.identifier.endpage1715en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue8en_US
dc.identifier.pmid23932610en_US
dc.identifier.scopus2-s2.0-84881458752en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1707en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2012.12.054
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23819
dc.identifier.volume48en_US
dc.identifier.wosWOS:000323413000013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Pediatric Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSildenafilen_US
dc.subjectIntestineen_US
dc.subjectIschemia-Reperfusionen_US
dc.subjectLiveren_US
dc.subjectIntestinal Ischemia/Reperfusion-Induced Liver Injuryen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectNitric-Oxideen_US
dc.subjectLung Injuryen_US
dc.subjectRat-Liveren_US
dc.subjectDysfunctionen_US
dc.subjectMechanismsen_US
dc.subjectVardenafilen_US
dc.subjectCirrhosisen_US
dc.subjectCitrateen_US
dc.subjectMiceen_US
dc.titleProtective effect of sildenafil on liver injury induced by intestinal ischemia/reperfusionen_US
dc.typeArticleen_US

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