Bioactivities of Alchemilla mollis, Alchemilla persica and Their Active Constituents

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dc.authoridEryilmaz, Mujde/0000-0003-3760-1996;
dc.authorwosidEryilmaz, Mujde/AAG-8316-2019
dc.authorwosidYILMAZ, Sezen/A-4724-2017
dc.contributor.authorKurtul, Ekin
dc.contributor.authorEryilmaz, Mujde
dc.contributor.authorSarialtin, Sezen Yilmaz
dc.contributor.authorTekin, Mehmet
dc.contributor.authorAcikara, Ozlem Bahadir
dc.contributor.authorCoban, Tulay
dc.date.accessioned2024-06-12T10:51:07Z
dc.date.available2024-06-12T10:51:07Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to determine antimicrobial activities of Alchemilla mollis, Alchemilla persica as well as ellagic acid and miquelianin against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans by using microbroth dilution method and anti-inflammatory activity by using human red blood cell (HRBC) membrane stabilization method. Microbroth dilution method was used to determine the antimicrobial activities. Extracts possessed activity having MIC values of 2.5-5-10mg/mL, compounds possessed activity having MIC values of 1.25-2.5- 4-5mg/mL. A.mollis aerial parts displayed the highest anti-inflammatory activity (IC50=1.22 +/- 0.07mg/mL). Ellagic acid and miquelianin were also determined as anti-inflammatory agents with 0.57 +/- 0.01mg/mL and 1.23 +/- 0.02mg/mL IC50 values, respectively. Total phenolic content and tannin content of the A.mollis and A.persica were determined as 357.00 +/- 75.80mg, 282.50 +/- 28.70mg PGE/g plant material and 18.02%, 18.63% respectively according to the method described by European Pharmacopoeia. Ellagic acid, miquelianin and catechin were analyzed by HPLC. The highest catechin content was detected in A.persica roots (6.69 +/- 0.05g/100g plant material). A.mollis aerial parts contain higher miquelianin (0.39 +/- 0.02g/plant material) and ellagic acid (1.56 +/- 0.01g/plant material) than A.persica.en_US
dc.identifier.doi10.1590/s2175-97902022e18373
dc.identifier.issn1984-8250
dc.identifier.issn2175-9790
dc.identifier.scopus2-s2.0-85127043513en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1590/s2175-97902022e18373
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18252
dc.identifier.volume58en_US
dc.identifier.wosWOS:000771764000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniv Sao Paulo, Conjunto Quimicasen_US
dc.relation.ispartofBrazilian Journal Of Pharmaceutical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlchemilla Mollisen_US
dc.subjectAlchemilla Persicaen_US
dc.subjectAnti-Inflammatory Activityen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectMiquelianinen_US
dc.subjectEllagic Aciden_US
dc.subjectBiological Activities Of Alchemilla Speciesen_US
dc.subjectSupplement Floraen_US
dc.subjectAdditional Taxaen_US
dc.subjectEllagic-Aciden_US
dc.subjectPlantsen_US
dc.subjectChecklisten_US
dc.subjectGrowthen_US
dc.titleBioactivities of Alchemilla mollis, Alchemilla persica and Their Active Constituentsen_US
dc.typeArticleen_US

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