Bioactivities of Alchemilla mollis, Alchemilla persica and Their Active Constituents
Küçük Resim Yok
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Univ Sao Paulo, Conjunto Quimicas
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study was to determine antimicrobial activities of Alchemilla mollis, Alchemilla persica as well as ellagic acid and miquelianin against Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Candida albicans by using microbroth dilution method and anti-inflammatory activity by using human red blood cell (HRBC) membrane stabilization method. Microbroth dilution method was used to determine the antimicrobial activities. Extracts possessed activity having MIC values of 2.5-5-10mg/mL, compounds possessed activity having MIC values of 1.25-2.5- 4-5mg/mL. A.mollis aerial parts displayed the highest anti-inflammatory activity (IC50=1.22 +/- 0.07mg/mL). Ellagic acid and miquelianin were also determined as anti-inflammatory agents with 0.57 +/- 0.01mg/mL and 1.23 +/- 0.02mg/mL IC50 values, respectively. Total phenolic content and tannin content of the A.mollis and A.persica were determined as 357.00 +/- 75.80mg, 282.50 +/- 28.70mg PGE/g plant material and 18.02%, 18.63% respectively according to the method described by European Pharmacopoeia. Ellagic acid, miquelianin and catechin were analyzed by HPLC. The highest catechin content was detected in A.persica roots (6.69 +/- 0.05g/100g plant material). A.mollis aerial parts contain higher miquelianin (0.39 +/- 0.02g/plant material) and ellagic acid (1.56 +/- 0.01g/plant material) than A.persica.
Açıklama
Anahtar Kelimeler
Alchemilla Mollis, Alchemilla Persica, Anti-Inflammatory Activity, Antimicrobial Activity, Miquelianin, Ellagic Acid, Biological Activities Of Alchemilla Species, Supplement Flora, Additional Taxa, Ellagic-Acid, Plants, Checklist, Growth
Kaynak
Brazilian Journal Of Pharmaceutical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
58
