Noncovalent Pyrene-Polyethylene Glycol Coatings of Carbon Nanotubes Achieve in Vitro Biocompatibility

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dc.authoridhttp://orcid.org/0000-0001-6033-7148en_US
dc.contributor.authorMeran, Mehdi
dc.contributor.authorAkkus, Pelin Deniz
dc.contributor.authorKurkcuoglu, Ozge
dc.contributor.authorBaysak, Elif
dc.contributor.authorHizal, Gurkan
dc.contributor.authorHaciosmanoglu, Ebru
dc.contributor.authorUnlu, Ayhan
dc.contributor.authorKaratepe, Nilgun
dc.contributor.authorGuner, F. Seniha
dc.date.accessioned2019-12-20T12:19:29Z
dc.date.available2019-12-20T12:19:29Z
dc.date.issued2018
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyofizik Anabilim Dalıen_US
dc.description.abstractSingle-walled carbon nanotubes (SWNTs) have become increasingly exploited in biological applications, such as imaging and drug delivery. The application of SWNTs in biological settings requires the surface chemistry to remain through the low solubility in aqueous media. In this research, a facile approach for the preparation of a polyethylene glycol (PEG)-coated SWNT-based nanocarrier was reported. We focused on the effect of PEG chain length and SWNT size on the cytotoxicity of PEG coated SWNTs as a superior drug delivery nanovector. First, all-atom molecular dynamics (MD) simulations were employed to explore the stability and behavior of SWNT/pyrene-PEG (SWNT/Pyr-PEG) structures at a molecular level that is not attainable with experiments. The MD studies revealed that (i) a pi-pi stacking interactions between the pyrene bearing PEG molecules and SWNTs are maintained in bulky situations, regardless of PEG molecular weight or SWNT size; (ii) pyrene molecules diffuse over the SWNT surface without detaching; and (iii) both short and long dynamic Pyr-PEG chains have the capability of effectively coating the SWNT surface. In light of the simulations, noncovalent (pi-pi stacking) assemblies of SWNT/Pyr-PEG with different molecular weights of PEG (M-W = 2000, 5000, and 12000) were successfully fabricated and characterized. For longer PEG chains, more effective coating of SWNTs was obtained, resulting in more biocompatible SWNT/Pyr-PEG nanomaterials. The number of SWNTs coated by Pyr-PEG was highly dependent on the length of pyrene bearing PEG polymers. Moreover, the short SWNTs showed a higher amount of PEG coating with respect to the long SWNTs. Cell viability results demonstrated a dose-dependent cytotoxicity of coated SWNTs. Short SWNTs coated with longer PEG chains have low cytotoxicity to be used in in vivo studies.en_US
dc.identifier.citationMeran, M., Akkus, P. D., Kurkcuoglu, O., Baysak, E., Hizal, G., Haciosmanoglu, E., ... & Güner, F. S. (2018). Noncovalent Pyrene-Polyethylene Glycol Coatings of Carbon Nanotubes Achieve in Vitro Biocompatibility. Langmuir, 34(40), 12071-12082.en_US
dc.identifier.doi10.1021/acs.langmuir.8b00971en_US
dc.identifier.endpage12082en_US
dc.identifier.issn0743-7463
dc.identifier.issue40en_US
dc.identifier.pmid30231197en_US
dc.identifier.scopus2-s2.0-85054207331en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage12071en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4855
dc.identifier.volume34en_US
dc.identifier.wosWOS:000447239100017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.relation.ispartofJournal Citation Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectMolecular-dynamics simulationen_US
dc.subjectAortic endothelial-cellsen_US
dc.subjectInitio force-fielden_US
dc.subjectPi-pi-interactionsen_US
dc.subjectPoly(ethylene glycol)en_US
dc.subjectDrug-deliveryen_US
dc.subjectBiomedical applicationsen_US
dc.subjectOxidative stressen_US
dc.subjectPolymeren_US
dc.subjectMechanismen_US
dc.titleNoncovalent Pyrene-Polyethylene Glycol Coatings of Carbon Nanotubes Achieve in Vitro Biocompatibilityen_US
dc.typeArticleen_US

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