Histopathological and immune alterations in autopsied kidneys
Küçük Resim Yok
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Saudi Med J
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: To collect data on all detectable histologic and immune alterations from the kidneys of 55 autopsy cases. Methods: This prospective study was carried out at the Department of Pathology, Medical Faculty, Trakya University, Edirne, Turkey. Fifty-five cases were subjected to the study among 248 autopsies that were performed in 2011 and 2012. All kidney samples were evaluated under a light microscope and fresh tissue samples were used for immunofluorescence microscopy. Immunohistochemically kappa (kappa) and lambda (lambda) antibodies were applied to the tissue sections. The glomerular, tubulo-interstitial, and vascular alterations, as well as immune depositions were noted. Results: The microscopic morphology was close to normal histology in only 23 cases, and 23 cases had glomerular alterations. Nineteen cases had at least one immune deposition. There was immunoglobulin A deposition in 13 cases, and 9 cases showed positivity for both. and. immunohistochemically, and there was no clonal positivity. Conclusion: The most striking outcome of our study is the high rate of immune depositions. There was also a significant number of glomerular and non-glomerular renal alterations.
Açıklama
Anahtar Kelimeler
Hepatitis-C Virus, Renal-Diseases, Iga Nephropathy, Biopsy, Glomerulonephritis, Classification, Population, Frequency, Registry, Risk
Kaynak
Saudi Medical Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
35
Sayı
11
