Small fiber neuropathy and related factors in patients with systemic lupus erythematosus; the results of cutaneous silent period and skin biopsy

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dc.contributor.authorTekatas, Aslan
dc.contributor.authorTekatas, Demet Deniz
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorKaraca, Turan
dc.contributor.authorPamuk, Omer Nuri
dc.date.accessioned2024-06-12T11:15:56Z
dc.date.available2024-06-12T11:15:56Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction Evaluating small nerve fibers in patients with systemic lupus erythematosus (SLE) using cutaneous silent period (CSP) and skin biopsy and assesssing the relationship between clinical signs, autoantibodies and neuropathic pain score. Objective - methods Fifty one SLE patients and 46 healthy volunteers were included in this study. Nerve conduction studies and CSP were performed both on upper and lower limbs in subjects. Skin biopsy was performed and the number of epidermal nerve density and IL-6 staining were evaluated. Results In SLE patients, CSP latencies were significantly prolonged both in lower and upper limbs and lower and upper extremity CSP durations were significantly shorter when compared to controls (p < 0.001). The number of epidermal nerve was significantly lower in SLE patients when compared to healthy controls (p < 0.001). Conclusion We detected marked small nerve fiber damage in both lower and upper limbs in SLE patients using CSP. Decreased epidermal nerve density also supports this finding.en_US
dc.identifier.doi10.1186/s42358-020-00133-9
dc.identifier.issn2523-3106
dc.identifier.issue1en_US
dc.identifier.pmid32503623en_US
dc.identifier.scopus2-s2.0-85086051255en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1186/s42358-020-00133-9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24134
dc.identifier.volume60en_US
dc.identifier.wosWOS:000540261600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofAdvances In Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.subjectCutaneous Silent Perioden_US
dc.subjectSmall Fiber Neuropathyen_US
dc.subjectEpidermal Nerve Densityen_US
dc.subjectElectromyographyen_US
dc.subjectPeripheral Neuropathyen_US
dc.subjectSensory Neuropathyen_US
dc.subjectClinical-Featuresen_US
dc.subjectRevised Criteriaen_US
dc.subjectLeeds Assessmenten_US
dc.subjectPain Scaleen_US
dc.subjectClassificationen_US
dc.subjectNerveen_US
dc.subjectSymptomsen_US
dc.subjectValidationen_US
dc.titleSmall fiber neuropathy and related factors in patients with systemic lupus erythematosus; the results of cutaneous silent period and skin biopsyen_US
dc.typeArticleen_US

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