Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 ?-Lactamase

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dc.authoridBolelli, Kayhan/0000-0002-2179-997X
dc.authoridAKI, Esin/0000-0002-1560-710X
dc.authorwosidOkten, Suzan/HGV-1334-2022
dc.authorwosidONURDAG, Fatma KAYNAK/T-2518-2017
dc.authorwosidÖkten, Suzan/HJH-6316-2023
dc.authorwosidErtan-Bolelli, Tugba/G-2237-2014
dc.authorwosidBolelli, Kayhan/G-5289-2013
dc.authorwosidAKI, Esin/U-4641-2019
dc.contributor.authorErtan-Bolelli, Tugba
dc.contributor.authorBolelli, Kayhan
dc.contributor.authorOkten, Suzan
dc.contributor.authorKaynak-Onurdag, Fatma
dc.contributor.authorAki-Yalcin, Esin
dc.contributor.authorYalcin, Ismail
dc.date.accessioned2024-06-12T10:52:00Z
dc.date.available2024-06-12T10:52:00Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractbeta-Lactam antibiotics are frequently used for treatment of multi-drug resistant microbial infections and the most common mechanism of resistance against these antibiotics is bacterial beta-lactamase production. Herein, we reported the design, synthesis and in vitro antimicrobial activities of some new 2-substituted-5-(2,4-dinitrophenylsulfonamido) benzoxazole derivatives. Compounds TN1, TN2, and TN3 were found to be significantly active against E. coli isolate which contains extended spectrum beta-lactamase enzyme at the MIC value of 8 mu g mL(-1) and that is 4-fold higher than the reference drug ampicillin. We performed molecular docking studies into active site of Escherichia coli TEM-1 beta-lactamase enzyme in order to predict the protein-ligand interactions. According to the docking results, compounds TN1, TN2, and TN3 showed strong interactions between the important active site residues which are responsible for the catalytic mechanism of TEM-1 beta-lactamase enzyme and a good correlation is found with the experimental data.en_US
dc.identifier.doi10.5562/cca3111
dc.identifier.endpage74en_US
dc.identifier.issn0011-1643
dc.identifier.issn1334-417X
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85020750100en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage67en_US
dc.identifier.urihttps://doi.org/10.5562/cca3111
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18564
dc.identifier.volume90en_US
dc.identifier.wosWOS:000412096200008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCroatian Chemical Socen_US
dc.relation.ispartofCroatica Chemica Actaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectBenzoxazoleen_US
dc.subjectEscherichia Colien_US
dc.subjectBeta-Lactamaseen_US
dc.subjectMolecular Dockingen_US
dc.subjectSulfonamideen_US
dc.subjectInhibitorsen_US
dc.subjectDerivativesen_US
dc.subjectCatalysisen_US
dc.subjectEvolutionen_US
dc.subjectEnzymeen_US
dc.titleSynthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 ?-Lactamaseen_US
dc.typeArticleen_US

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