Synthesis, Antimicrobial Activities of New Sulfonamidobenzoxazoles and Molecular Docking Studies on Escherichia coli TEM-1 ?-Lactamase
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Croatian Chemical Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
beta-Lactam antibiotics are frequently used for treatment of multi-drug resistant microbial infections and the most common mechanism of resistance against these antibiotics is bacterial beta-lactamase production. Herein, we reported the design, synthesis and in vitro antimicrobial activities of some new 2-substituted-5-(2,4-dinitrophenylsulfonamido) benzoxazole derivatives. Compounds TN1, TN2, and TN3 were found to be significantly active against E. coli isolate which contains extended spectrum beta-lactamase enzyme at the MIC value of 8 mu g mL(-1) and that is 4-fold higher than the reference drug ampicillin. We performed molecular docking studies into active site of Escherichia coli TEM-1 beta-lactamase enzyme in order to predict the protein-ligand interactions. According to the docking results, compounds TN1, TN2, and TN3 showed strong interactions between the important active site residues which are responsible for the catalytic mechanism of TEM-1 beta-lactamase enzyme and a good correlation is found with the experimental data.
Açıklama
Anahtar Kelimeler
Antimicrobial Activity, Benzoxazole, Escherichia Coli, Beta-Lactamase, Molecular Docking, Sulfonamide, Inhibitors, Derivatives, Catalysis, Evolution, Enzyme
Kaynak
Croatica Chemica Acta
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
90
Sayı
1
