Association between Localized Scleroderma Cutaneous Assessment Tool and clinicopathologic characteristics in patients with morphea

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dc.authoridGURSEL URUN, Yildiz/0000-0002-6137-8395
dc.contributor.authorUrun, Yildiz Gursel
dc.contributor.authorKeskin, Elif Usturali
dc.date.accessioned2024-06-12T11:07:46Z
dc.date.available2024-06-12T11:07:46Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Design: Morphea is also known as localized scleroderma. It is a rare autoimmune skin disease characterized by inflammation and sclerosis in the dermis and sometimes in the subcutaneous tissue. Laboratory findings, imaging, and histopathological features facilitate diagnosis and provide sufficient information about disease severity. Clinicopathologic correlations and severity factors in morphea are poorly described. Thus, this study aimed to review the clinical and histopathological features and treatment responses of patients with morphea and compare these features with disease activity and damage scores to identify new tools for assessing disease severity other than clinical findings. The applicability of the Localized Scleroderma Cutaneous Assessment Tool in clinical practice was also evaluated.Materials and Methods: This study reviewed data of 41 patients who had a histopathologically confirmed diagnosis of morphea and had been followed up regularly for at least 6 months. The modified Localized Scleroderma Skin Severity Index (mLoSSI), Localized Scleroderma Skin Damage Index (LoSDI), Physician Global Assessment-Activity (PGA-A), and Physician Global Assessment-Damage (PGA-D) were calculated at baseline and final treatment.Results: Among morphea subtypes, superficial morphea had significantly more sclerosis in the papillary dermis and plaque-type morphea had significantly more sclerosis in the reticular dermis (p<0.05). When positive antinuclear antibody (ANA) and high levels of thyroid autoantibodies were compared with mLoSSI, LoSDI, PGA-A, and PGA-D scores at baseline, no significant correlation was found. Comparison of the subgroups according to the initial mLoSSI and LoSDI scores revealed no significant histopathological differences between the groups.Conclusion: Although the mLoSSI, LoSDI, PGA-A, and PGA-D scores can be successfully used for the follow-up and treatment of patients with morphea, no correlation was found between positive ANA, high levels of thyroid autoantibodies, and histopathological features.en_US
dc.identifier.doi10.4274/turkderm.galenos.2022.07347
dc.identifier.endpage102en_US
dc.identifier.issn2717-6398
dc.identifier.issn2651-5164
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85150472617en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage93en_US
dc.identifier.trdizinid1134603en_US
dc.identifier.urihttps://doi.org/10.4274/turkderm.galenos.2022.07347
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1134603
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22181
dc.identifier.volume56en_US
dc.identifier.wosWOS:000870186000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkderm-Turkish Archives Of Dermatology And Venerologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLocalized Sclerodermaen_US
dc.subjectMorpheaen_US
dc.subjectLocalized Scleroderma Cutaneous Assessment Toolen_US
dc.subjectPathologyen_US
dc.subjectAutoantibodiesen_US
dc.subjectClinical Characteristicsen_US
dc.subjectEosinophilic Fasciitisen_US
dc.subjectAdultsen_US
dc.subjectFeaturesen_US
dc.subjectDiseaseen_US
dc.subjectRecurrenceen_US
dc.subjectDiagnosisen_US
dc.subjectOutcomesen_US
dc.subjectDermisen_US
dc.subjectSkinen_US
dc.titleAssociation between Localized Scleroderma Cutaneous Assessment Tool and clinicopathologic characteristics in patients with morpheaen_US
dc.typeArticleen_US

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