Oral Immunotherapy in Food Allergy: Where Are We Now?

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dc.authoridYanagida, Noriyuki/0000-0001-9643-744X
dc.authoridEbisawa, Motohiro/0000-0003-4117-558X
dc.contributor.authorOzdemir, Pinar Gokmirza
dc.contributor.authorSato, Sakura
dc.contributor.authorYanagida, Noriyuki
dc.contributor.authorEbisawa, Motohiro
dc.date.accessioned2024-06-12T10:51:37Z
dc.date.available2024-06-12T10:51:37Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractFood allergy (FA) has become more prevalent and problematic in the last 2 decades, and it poses important individual, social, and economic burdens. Besides treating reactions induced by accidental exposure and periodic evaluation for acquiring natural tolerance, the primary management approach is still allergen avoidance as a global standard. However, an active therapeutic approach that can raise the reaction threshold or accelerate tolerance is needed. This review aimed to provide an overview and the latest evidence of oral immunotherapy (OIT), which has recently been used in the active treatment of FA. FA immunotherapy, particularly OIT, is gaining considerable interest, and substantial effort has been made to integrate this active treatment into clinical practice. Consequently, growing evidence has been obtained regarding the efficacy and safety of OIT, particularly for allergens such as peanuts, eggs, and milk. However, several issues need to be addressed regarding the availability, safety, and long-term effects of this intervention. In this review, we summarize currently available information regarding tolerance-inducing immune mechanisms of OIT, data on efficacy and safety, gaps in current evidence, and ongoing research to develop new therapeutic molecules in order to enhance safety.en_US
dc.description.sponsorshipGrants-in-Aid for Scientific Research [21K03123] Funding Source: KAKENen_US
dc.identifier.doi10.4168/aair.2023.15.2.125
dc.identifier.endpage144en_US
dc.identifier.issn2092-7355
dc.identifier.issn2092-7363
dc.identifier.issue2en_US
dc.identifier.pmid37021501en_US
dc.identifier.scopus2-s2.0-85159281848en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.4168/aair.2023.15.2.125
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18420
dc.identifier.volume15en_US
dc.identifier.wosWOS:000969310900003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKorean Acad Asthma Allergy & Clinical Immunologyen_US
dc.relation.ispartofAllergy Asthma & Immunology Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAnaphylaxisen_US
dc.subjectFood Allergyen_US
dc.subjectOral Immunotherapyen_US
dc.subjectToleranceen_US
dc.subjectCell Epitope Peptidesen_US
dc.subjectPeanut Allergyen_US
dc.subjectEgg Allergyen_US
dc.subjectSustained Unresponsivenessen_US
dc.subjectMurine Modelen_US
dc.subjectDouble-Blinden_US
dc.subjectChildrenen_US
dc.subjectEfficacyen_US
dc.subjectSafetyen_US
dc.subjectToleranceen_US
dc.titleOral Immunotherapy in Food Allergy: Where Are We Now?en_US
dc.typeReview Articleen_US

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