Oral Immunotherapy in Food Allergy: Where Are We Now?
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Korean Acad Asthma Allergy & Clinical Immunology
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Food allergy (FA) has become more prevalent and problematic in the last 2 decades, and it poses important individual, social, and economic burdens. Besides treating reactions induced by accidental exposure and periodic evaluation for acquiring natural tolerance, the primary management approach is still allergen avoidance as a global standard. However, an active therapeutic approach that can raise the reaction threshold or accelerate tolerance is needed. This review aimed to provide an overview and the latest evidence of oral immunotherapy (OIT), which has recently been used in the active treatment of FA. FA immunotherapy, particularly OIT, is gaining considerable interest, and substantial effort has been made to integrate this active treatment into clinical practice. Consequently, growing evidence has been obtained regarding the efficacy and safety of OIT, particularly for allergens such as peanuts, eggs, and milk. However, several issues need to be addressed regarding the availability, safety, and long-term effects of this intervention. In this review, we summarize currently available information regarding tolerance-inducing immune mechanisms of OIT, data on efficacy and safety, gaps in current evidence, and ongoing research to develop new therapeutic molecules in order to enhance safety.
Açıklama
Anahtar Kelimeler
Anaphylaxis, Food Allergy, Oral Immunotherapy, Tolerance, Cell Epitope Peptides, Peanut Allergy, Egg Allergy, Sustained Unresponsiveness, Murine Model, Double-Blind, Children, Efficacy, Safety, Tolerance
Kaynak
Allergy Asthma & Immunology Research
WoS Q Değeri
N/A
Scopus Q Değeri
Q2
Cilt
15
Sayı
2
