Protective effects of a-lipoic acid and chondroitin-4-sulfate against benomyl-induced toxicity in rats

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dc.contributor.authorBalkan, Seda
dc.contributor.authorAktac, Tulin
dc.date.accessioned2024-06-12T10:54:22Z
dc.date.available2024-06-12T10:54:22Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn this study, the effects of fungicide benomyl and the protective effects of -lipoic acid (LA) and chondroitin-4-sulfate (C4S) used as antioxidants on liver and kidney of rats were investigated. Benomyl (200mg kg(-1)), LA (200mg kg(-1)), and C4S (25mgkg(-1)) were administered intraperitoneally by injection once a week for a period of five weeks. The results of this study are as follows: benomyl given subchronically showed toxic effects in the form of lipid peroxidation (LPO) on liver and kidney, and LA and C4S had antioxidant effects on liver and kidney. When LA and C4S were applied together, they were more effective than individually. Furthermore, it was observed that LA and C4S had partial protective effects against the histopathological effects caused by benomyl.en_US
dc.description.sponsorshipTrakya University Research Foundation [TUBAB-906]en_US
dc.description.sponsorshipTrakya University Research Foundation provided the financial support for this work (TUBAB-906).en_US
dc.identifier.doi10.1080/02772248.2014.897707
dc.identifier.endpage1721en_US
dc.identifier.issn0277-2248
dc.identifier.issn1029-0486
dc.identifier.issue10en_US
dc.identifier.scopus2-s2.0-84901001844en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1712en_US
dc.identifier.urihttps://doi.org/10.1080/02772248.2014.897707
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19027
dc.identifier.volume95en_US
dc.identifier.wosWOS:000335944300008en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofToxicological And Environmental Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenomylen_US
dc.subjectLipid Peroxidationen_US
dc.subject-Lipoic Aciden_US
dc.subjectChondroitin-4-Sulfateen_US
dc.subjectAntioxidanten_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectIn-Vitroen_US
dc.subjectAntioxidanten_US
dc.subjectGlycosaminoglycansen_US
dc.subjectSulfateen_US
dc.subjectSystemen_US
dc.titleProtective effects of a-lipoic acid and chondroitin-4-sulfate against benomyl-induced toxicity in ratsen_US
dc.typeArticleen_US

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