Protective effects of a-lipoic acid and chondroitin-4-sulfate against benomyl-induced toxicity in rats
Küçük Resim Yok
Tarih
2013
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the effects of fungicide benomyl and the protective effects of -lipoic acid (LA) and chondroitin-4-sulfate (C4S) used as antioxidants on liver and kidney of rats were investigated. Benomyl (200mg kg(-1)), LA (200mg kg(-1)), and C4S (25mgkg(-1)) were administered intraperitoneally by injection once a week for a period of five weeks. The results of this study are as follows: benomyl given subchronically showed toxic effects in the form of lipid peroxidation (LPO) on liver and kidney, and LA and C4S had antioxidant effects on liver and kidney. When LA and C4S were applied together, they were more effective than individually. Furthermore, it was observed that LA and C4S had partial protective effects against the histopathological effects caused by benomyl.
Açıklama
Anahtar Kelimeler
Benomyl, Lipid Peroxidation, -Lipoic Acid, Chondroitin-4-Sulfate, Antioxidant, Induced Oxidative Stress, Lipid-Peroxidation, In-Vitro, Antioxidant, Glycosaminoglycans, Sulfate, System
Kaynak
Toxicological And Environmental Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
95
Sayı
10
