Importance of internal mammary artery perfusion in cardiac ischemia and reperfusion

Basit Öğe Kaydı
dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.contributor.authorEge, T
dc.contributor.authorEskiocak, S
dc.contributor.authorYuksel, V
dc.contributor.authorTaskiran, A
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T11:19:11Z
dc.date.available2024-06-12T11:19:11Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Our purpose was to investigate the changes in antioxidant defense systems due to internal mammary artery (IMA) perfusion during coronary artery bypass graft (CABG) operations in which proximal anastomoses were completed under partial bypass with the aid of a side-biting clamp. Material and Method: Twenty-five patients to be studied were divided into two groups according to the criterion of whether during proximal anastomoses left internal mammary artery (LIMA) perfusion was applied (n = 15, LIMA group) or not (n = 10, non-LIMA group). The erythrocyte catalase (CAT), superoxide dismutase (SOD), serum lipid peroxidation (LPO) products and whole blood reduced glutathione (GSH) levels were measured in the blood samples taken from the coronary sinus before cardiopulmonary bypass (CPB) (t(1)), before declamping (t(2)), at the 5th min after declamping (t(3)) at the 5th (t(4)) and 15th (t(5)) min after removing the side-biting clamp. Results: While erythrocyte CAT enzyme activity decreases in both groups after the basal measurements, no significant difference was detected between the groups. Although the GSH levels did not differ at t(1), t(2) and t(3), they were found to be higher in the LIMA group at t(4) (p = 0.006) and t(5) (p = 0.021). The erythrocyte SOD enzyme activity decreased after the basal measurements in both groups, but this reduction was less in the LIMA group at t(4) (p = 0.034) and t(5) (p = 0.018) compared to the other group. LPO products rose in both groups when reperfusion started after declamping. The levels of LPO products were significantly higher at t(4) and t(5) in the non-LIMA group than the other group (p = 0.011 and p = 0.008). Conclusion: If proximal anastomoses of coronary grafts are completed under partial bypass, permitting LIMA perfusion during this procedure will be beneficial to antioxidant defense systems.en_US
dc.identifier.doi10.1191/0267659103pf694oa
dc.identifier.endpage356en_US
dc.identifier.issn0267-6591
dc.identifier.issn1477-111X
dc.identifier.issue6en_US
dc.identifier.pmid14714770en_US
dc.identifier.scopus2-s2.0-0347126967en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage351en_US
dc.identifier.urihttps://doi.org/10.1191/0267659103pf694oa
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25090
dc.identifier.volume18en_US
dc.identifier.wosWOS:000187925900004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofPerfusion-Uken_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInduced Oxidative Stressen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectBlooden_US
dc.subjectMechanismsen_US
dc.subjectCatalaseen_US
dc.subjectSurgeryen_US
dc.subjectEnzymesen_US
dc.subjectCellsen_US
dc.subjectHearten_US
dc.titleImportance of internal mammary artery perfusion in cardiac ischemia and reperfusionen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu