Importance of internal mammary artery perfusion in cardiac ischemia and reperfusion
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Sage Publications Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Purpose: Our purpose was to investigate the changes in antioxidant defense systems due to internal mammary artery (IMA) perfusion during coronary artery bypass graft (CABG) operations in which proximal anastomoses were completed under partial bypass with the aid of a side-biting clamp. Material and Method: Twenty-five patients to be studied were divided into two groups according to the criterion of whether during proximal anastomoses left internal mammary artery (LIMA) perfusion was applied (n = 15, LIMA group) or not (n = 10, non-LIMA group). The erythrocyte catalase (CAT), superoxide dismutase (SOD), serum lipid peroxidation (LPO) products and whole blood reduced glutathione (GSH) levels were measured in the blood samples taken from the coronary sinus before cardiopulmonary bypass (CPB) (t(1)), before declamping (t(2)), at the 5th min after declamping (t(3)) at the 5th (t(4)) and 15th (t(5)) min after removing the side-biting clamp. Results: While erythrocyte CAT enzyme activity decreases in both groups after the basal measurements, no significant difference was detected between the groups. Although the GSH levels did not differ at t(1), t(2) and t(3), they were found to be higher in the LIMA group at t(4) (p = 0.006) and t(5) (p = 0.021). The erythrocyte SOD enzyme activity decreased after the basal measurements in both groups, but this reduction was less in the LIMA group at t(4) (p = 0.034) and t(5) (p = 0.018) compared to the other group. LPO products rose in both groups when reperfusion started after declamping. The levels of LPO products were significantly higher at t(4) and t(5) in the non-LIMA group than the other group (p = 0.011 and p = 0.008). Conclusion: If proximal anastomoses of coronary grafts are completed under partial bypass, permitting LIMA perfusion during this procedure will be beneficial to antioxidant defense systems.
Açıklama
Anahtar Kelimeler
Induced Oxidative Stress, Lipid-Peroxidation, Superoxide-Dismutase, Blood, Mechanisms, Catalase, Surgery, Enzymes, Cells, Heart
Kaynak
Perfusion-Uk
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
18
Sayı
6
