Evaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugs

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dc.authoridOltulu, Cagatay/0000-0002-6051-3479
dc.authoridYesil, Tugce/0000-0002-7157-3442
dc.authoridAkgul obeidin, Vildan/0000-0003-0138-2445
dc.authorwosidOLMEZ, SEVCAN GUL AKGUN/AAD-3028-2019
dc.authorwosidOltulu, Cagatay/V-1823-2018
dc.authorwosidYesil, Tugce/AAF-2523-2019
dc.contributor.authorOltulu, Cagatay
dc.contributor.authorYesil Devecioglu, Tugce
dc.contributor.authorAkinci, Melek
dc.contributor.authorOlmez, Sevcan Gul Akgun
dc.contributor.authorObeidin, Serra Vildan Akgul
dc.contributor.authorBeceren, Ayfer
dc.date.accessioned2024-06-12T10:51:11Z
dc.date.available2024-06-12T10:51:11Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: DNA damage that can be caused by workplace exposure to antineoplastic drugs in health workers has been shown in many scientific studies. It is aimed to evaluate whether the risk of genotoxicity in health workers decreases after the regulations and measures taken by national and international health authorities in our work. Methods: For this purpose, DNA damage was assessed by using alkaline comet technique in lymphocytes isolated from blood samples of health workers (n=29) who were involved in preparing and/or administering antineoplastic agent at Trakya University Health Research and Application Center and compared with the control group (n=30). Also, those who prepare and/or administer antineoplastic agents; (n=16) and manual (n=13) preparations. Results: As a result of the evaluation, there was no statistically significant difference between health personnel and control group in preparing and / or administering antineoplastic agent (p>0,05, Mann-Whitney U) and there was no difference in the genotoxic risk between preparation forms. Furthermore, when the exposed control group was assessed for DNA damage as smokers and nonsmokers, there was no statistically significant difference in terms of DNA damage (p>0.05). Conclusion: At the center where our samples were taken, the resulting measures resulted in the control of the risk of genotoxicity due to occupational exposure to antineoplastic agents.en_US
dc.description.sponsorshipResearch Fund of the Trakya University [TUBAP 2015-37]en_US
dc.description.sponsorshipThis work was supported by Research Fund of the Trakya University. Project Number: TUBAP 2015-37.en_US
dc.identifier.doi10.33808/clinexphealthsci.563988
dc.identifier.endpage170en_US
dc.identifier.issn2459-1459
dc.identifier.issue2en_US
dc.identifier.startpage166en_US
dc.identifier.trdizinid375603en_US
dc.identifier.urihttps://doi.org/10.33808/clinexphealthsci.563988
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/375603
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18276
dc.identifier.volume9en_US
dc.identifier.wosWOS:000473218600012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherMarmara Univ, Inst Health Sciencesen_US
dc.relation.ispartofClinical And Experimental Health Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlkaline Comet Assayen_US
dc.subjectGenotoxicityen_US
dc.subjectAntineoplasticen_US
dc.subjectOccupational Exposureen_US
dc.subjectOccupational Health Safetyen_US
dc.subjectDna-Damageen_US
dc.subjectComet Assayen_US
dc.subjectNursesen_US
dc.subjectContaminationen_US
dc.subjectLymphocytesen_US
dc.subjectAssociationen_US
dc.subjectEnvironmenten_US
dc.subjectPopulationen_US
dc.subjectRepairen_US
dc.titleEvaluation of Genotoxicity Risk in Health Care Workers Exposed to Antineoplastic Drugsen_US
dc.typeArticleen_US

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