Effect of mitomycin-C applied through different approaches following tracheal surgery on development of granulation tissue and level of nephrotoxicity in rats

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dc.authoridkuzucuoğlu, mustafa/0000-0001-9889-0061
dc.authoridALTUN, EREN/0000-0001-9110-8364
dc.authorwosidkuzucuoğlu, mustafa/R-5469-2016
dc.authorwosidALTUN, EREN/P-1338-2019
dc.contributor.authorKuzucuoglu, Mustafa
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorAltun, Eren
dc.date.accessioned2024-06-12T11:02:48Z
dc.date.available2024-06-12T11:02:48Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: This study aims to evaluate the effect of mitomycin-C applied through different drug administration approaches on the development of granulation tissue in the field of surgery and renal functions in rats which underwent tracheal surgery. Methods: Fifty male adult Sprague Dawley rats (weighing mean 200 g to 300 g) were divided into five groups. An incision was performed between the fifth and sixth cartilage ring of the trachea in all groups under anesthesia and the incision was primarily repaired with a 6/0 monofilament absorbable suture. A single dose of mitomycin-C 0.5 mg was applied in the experimental animals appropriate with their assigned groups as topical, intraperitoneal injection, injection to the wound edges, and through inhalation. No mitomycin-C was administered in one group which was accepted as the control group. Rats were sacrificed four weeks after surgery and their tracheas were excised subsequently. Tracheal tissue samples were histopathologically evaluated in terms of epithelization, fibrosis, amount of fibroblasts, angiogenesis, and inflammatory response. Diameter and wall thickness of the tracheas were measured. Blood urea and creatinine levels were evaluated for nephrotoxicity, and the rats were immunohistochemically examined for glomerular pathology. Results: Epithelization was statistically significantly decelerated (p<0.01), diameter of the trachea was statistically significantly larger (p<0.05), and wall thickness of the trachea was significantly thicker in the group with topical mitomycin-C application compared to the control group (p<0.01). Conclusion: Topically applied mitomycin-C following tracheal surgery slows down epithelization and, thus, decreases the development of granulation tissue and maintains a wider diameter of the trachea.en_US
dc.identifier.doi10.5606/tgkdc.dergisi.2019.16337
dc.identifier.endpage79en_US
dc.identifier.issn1301-5680
dc.identifier.issue1en_US
dc.identifier.pmid32082830en_US
dc.identifier.scopus2-s2.0-85065037017en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage73en_US
dc.identifier.trdizinid338515en_US
dc.identifier.urihttps://doi.org/10.5606/tgkdc.dergisi.2019.16337
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/338515
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21412
dc.identifier.volume27en_US
dc.identifier.wosWOS:000455260600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal Of Thoracic And Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGranulation Tissueen_US
dc.subjectMitomycin-Cen_US
dc.subjectSurgeryen_US
dc.subjectTracheaen_US
dc.subjectTo-End Anastomosisen_US
dc.subjectSurgical-Treatmenten_US
dc.subjectStenosisen_US
dc.subjectResectionen_US
dc.titleEffect of mitomycin-C applied through different approaches following tracheal surgery on development of granulation tissue and level of nephrotoxicity in ratsen_US
dc.typeArticleen_US

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