Neuromuscular Morphometry of the Uterine Ligaments and Vaginal Wall in Women With Pelvic Organ Prolapse

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dc.authoridInal, Hasan/0000-0002-8361-7908;
dc.authorwosidInal, Hasan/F-9285-2015
dc.authorwosidTokuç, Burcu/ABF-7730-2021
dc.contributor.authorKaplan, Petek Balkanli
dc.contributor.authorUsta, Ufuk
dc.contributor.authorInal, Hasan Ali
dc.contributor.authorTastekin, Tugba
dc.contributor.authorTokuc, Burcu
dc.date.accessioned2024-06-12T11:12:11Z
dc.date.available2024-06-12T11:12:11Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAims: The aim of this study was to compare neuromuscular histomorphometry of the uterine ligaments and vaginal wall in women with and without pelvic organ prolapse. Methods: Biopsies were obtained from the round, uterosacral, and cardinal ligaments of the uterus and apical vaginal wall of women having pelvic organ prolapse repaired (stage >= II; prolapse group, 37) and the same location in patients with no prolapse (stage < II; control group, 47). Routine hematoxylin-eosin (H & E) staining and immunohistochemical staining for Protein Gene Product 9.5 (PGP 9.5) and smooth muscle alpha-actin were performed for all specimens. Results: Smooth muscle percentage of the uterosacral and cardinal ligaments were not significantly different in women with prolapse than in women without. In round ligament, mean smooth muscle percentage was lower than in women with normal support (81.63 +/- 8.2 vs. 51.63 +/- 16, P = 0.000). Mean distance of the smooth muscle fibers from surface epithelium of the vaginal epithelium of the women with prolapse were significantly higher than the control group (1.679 +/- 0.34 vs. 2.240 +/- 0.33, P = 0.000). PGP 9.5 stained area percentage of uterine ligaments and vaginal wall tissue samples were significantly lower in women with prolapse. Conclusions: Both total innervation of the anterior vaginal epithelium and uterine ligaments, and muscular percentage of the round ligament and vaginal wall were decreased in women with pelvic organ prolapse. Neurourol. Urodyn. 30: 126-132, 2011. (C) 2010 Wiley-Liss, Inc.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-800]en_US
dc.description.sponsorshipContract grant sponsor: Trakya University Research Council; Contract grant number: TUBAP-800.en_US
dc.identifier.doi10.1002/nau.20972
dc.identifier.endpage132en_US
dc.identifier.issn0733-2467
dc.identifier.issn1520-6777
dc.identifier.issue1en_US
dc.identifier.pmid21046656en_US
dc.identifier.scopus2-s2.0-78651069374en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://doi.org/10.1002/nau.20972
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23077
dc.identifier.volume30en_US
dc.identifier.wosWOS:000285980300023en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofNeurourology And Urodynamicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPelvic Organ Prolapseen_US
dc.subjectPGP 9.5en_US
dc.subjectUterine Ligamentsen_US
dc.subjectVaginal Wallen_US
dc.subjectAlpha-Actinen_US
dc.subjectGenitourinary Prolapseen_US
dc.subjectUterosacral Ligamenten_US
dc.subjectSmooth-Muscleen_US
dc.subjectStress-Incontinenceen_US
dc.subjectNerveen_US
dc.subjectFlooren_US
dc.subjectHysterectomyen_US
dc.subjectPathogenesisen_US
dc.subjectDenervationen_US
dc.subjectDensityen_US
dc.titleNeuromuscular Morphometry of the Uterine Ligaments and Vaginal Wall in Women With Pelvic Organ Prolapseen_US
dc.typeArticleen_US

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