Neuromuscular Morphometry of the Uterine Ligaments and Vaginal Wall in Women With Pelvic Organ Prolapse
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wiley
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aims: The aim of this study was to compare neuromuscular histomorphometry of the uterine ligaments and vaginal wall in women with and without pelvic organ prolapse. Methods: Biopsies were obtained from the round, uterosacral, and cardinal ligaments of the uterus and apical vaginal wall of women having pelvic organ prolapse repaired (stage >= II; prolapse group, 37) and the same location in patients with no prolapse (stage < II; control group, 47). Routine hematoxylin-eosin (H & E) staining and immunohistochemical staining for Protein Gene Product 9.5 (PGP 9.5) and smooth muscle alpha-actin were performed for all specimens. Results: Smooth muscle percentage of the uterosacral and cardinal ligaments were not significantly different in women with prolapse than in women without. In round ligament, mean smooth muscle percentage was lower than in women with normal support (81.63 +/- 8.2 vs. 51.63 +/- 16, P = 0.000). Mean distance of the smooth muscle fibers from surface epithelium of the vaginal epithelium of the women with prolapse were significantly higher than the control group (1.679 +/- 0.34 vs. 2.240 +/- 0.33, P = 0.000). PGP 9.5 stained area percentage of uterine ligaments and vaginal wall tissue samples were significantly lower in women with prolapse. Conclusions: Both total innervation of the anterior vaginal epithelium and uterine ligaments, and muscular percentage of the round ligament and vaginal wall were decreased in women with pelvic organ prolapse. Neurourol. Urodyn. 30: 126-132, 2011. (C) 2010 Wiley-Liss, Inc.
Açıklama
Anahtar Kelimeler
Pelvic Organ Prolapse, PGP 9.5, Uterine Ligaments, Vaginal Wall, Alpha-Actin, Genitourinary Prolapse, Uterosacral Ligament, Smooth-Muscle, Stress-Incontinence, Nerve, Floor, Hysterectomy, Pathogenesis, Denervation, Density
Kaynak
Neurourology And Urodynamics
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
30
Sayı
1
